Document Detail

Elastic behavior and structure of normal and emphysematous lungs post mortem.
MedLine Citation:
PMID:  7352696     Owner:  NLM     Status:  MEDLINE    
To examine the relationship between lung structure and function, static deflation pressure-volume curves were measured post mortem in 14 normal and 7 emphysematous lungs, and the results were compared to morphometric measurements of lung. Elastic behavior was described satisfactorily by an exponential function: V = A -Be-KP, where V is lung volume, P is static recoil pressure, and A, B, and K are constants. The constant K, an index of pulmonary elasticity, was closely related to a morphometric measurement of mean alveolar size. In normal lungs the decrease in pulmonary elasticity with age was quantified by an increase in K. When emphysema was present, K was invariably increased by more than 2 SD above the mean predicted value for age, reflecting the abnormally increased distensibility of alveoli in this disorder. The present findings indicate that a similar analysis of pressure-volume measurements obtained during life will reliably detect the presence of pulmonary emphysema in patients with chronic airflow limitation.
I A Greaves; H J Colebatch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  121     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-36     Citation Subset:  AIM; IM    
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MeSH Terms
Lung Compliance
Middle Aged
Pulmonary Alveoli / anatomy & histology,  pathology,  physiopathology*
Pulmonary Emphysema / pathology,  physiopathology*

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