Document Detail


Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography.
MedLine Citation:
PMID:  20851930     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing.
OBJECTIVES: To use anatomical optical coherence tomography (aOCT) to compare central airway elastic properties in control subjects and those with obstructive lung diseases.
METHODS: After bronchodilation, airway lumen area (Ai) was measured using aOCT during bronchoscopy in control subjects (n = 10) and those with asthma (n = 16), chronic obstructive pulmonary disease (COPD) (n = 9), and bronchiectasis (n = 8). Ai was measured in each of generations 0 to 5 while airway pressure was increased from -10 to 20 cm H(2)O. Airway compliance (Caw) and specific compliance (sCaw) were derived from the transpulmonary pressure (Pl) versus Ai curves.
MEASUREMENTS AND MAIN RESULTS: Caw decreased progressively as airway generation increased, but sCaw did not differ appreciably across the generations. In subjects with asthma and bronchiectasis, Caw and sCaw were similar to control subjects and the Pl-Ai curves were left-shifted. No significant differences were observed between control and COPD groups.
CONCLUSIONS: Proximal airway elastic properties are altered in obstructive lung diseases. Although central airway compliance does not differ from control subjects in asthma, bronchiectasis, or COPD, Ai is lower in asthma and the Pl-Ai relationship is left-shifted in both asthma and bronchiectasis, suggesting that airways are maximally distended at lower inflating pressures. Such changes reflect alteration in the balance between airway wall distensibility and radial traction exerted on airways by surrounding lung parenchyma favoring airway narrowing. Clinical trial registered with Australian New Zealand Clinical Trials Registry (ACTRN12607000624482).
Authors:
Jonathan P Williamson; Robert A McLaughlin; William J Noffsinger; Alan L James; Vanessa A Baker; Andrea Curatolo; Julian J Armstrong; Adrian Regli; Kelly L Shepherd; Guy B Marks; David D Sampson; David R Hillman; Peter R Eastwood
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-17
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  183     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-06-16     Revised Date:  2013-02-11    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  612-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Australia. jonowilliamson@ozemail.com.au
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bronchoscopy
Elasticity
Female
Humans
Lung / physiopathology
Lung Compliance
Lung Diseases, Obstructive / physiopathology*
Male
Middle Aged
Tomography, Optical Coherence / methods*
Young Adult
Comments/Corrections
Comment In:
Am J Respir Crit Care Med. 2011 Mar 1;183(5):563-4   [PMID:  21471052 ]
Am J Respir Crit Care Med. 2013 Jan 1;187(1):107-8   [PMID:  23281353 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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