Document Detail


Elastase is associated with the neurofibrillary pathology of Alzheimer disease: a putative link between proteolytic imbalance and oxidative stress.
MedLine Citation:
PMID:  21551909     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study demonstrates elastase immunoreactivity in the neurofibrillary pathology of Alzheimer disease. Using an antiserum against elastase, we show that elastase immunoreactivity is restricted to neurons and is markedly elevated in a proportion of neurofibrillary tangle-bearing neurons. Elastase is a proteolytic enzyme that might be a candidate protease for the generation of amyloid-β from β-protein precursor. These findings support the hypothesis that proteases play an important role in Alzheimer disease and furthers the notion that an imbalance in proteolytic regulation contributes towards the pathogenic presentation of the disease. Moreover, since α1-antitrypsin, the principal inhibitor of elastase, is highly susceptible to oxidative stress, our findings suggest a link between proteolytic imbalance and oxidative stress in the pathogenesis of Alzheimer disease.
Authors:
M A Smith; P L Richey; R N Kalaria; G Perry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Restorative neurology and neuroscience     Volume:  9     ISSN:  0922-6028     ISO Abbreviation:  Restor. Neurol. Neurosci.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  2011-05-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005499     Medline TA:  Restor Neurol Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  -    
Affiliation:
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road Cleveland, Ohio 44106, USA.
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