| Elaboration of both the group W135 and group Y capsular polysccharides by a single strain of Neisseria meningitidis. | |
MedLine Citation:
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PMID: 6775049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single strain (8021) of Neisseria meningitidis, isolated from a child with disseminated meningococcal disease, was found to elaborate two serogroup-specific capsular polysaccharides-Y and W135. The original isolate as well as the progeny of ten single colony sub-isolates each agglutinated with both group Y and group W135 serogrouping antisera. The capsular polysccharide of strain 8021 contained the chemical constituents of both the W135 and Y capsular polysaccharides in a ratio of about 2.5:1. The patient responded immunologically to both capsular polysaccharides with haemagglutinating antibodies. Analysis by double diffusion in agar revealed that the capsular polysaccharide of strain 8021 contained individual molecules of group W135 and group Y capsular polysaccharides as well as a mosaic molecule containing both antigenic determinants. |
Authors:
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B L Brandt; G B Pier; D K Goroff; P L Altieri; J M Griffiss |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of general microbiology Volume: 118 ISSN: 0022-1287 ISO Abbreviation: J. Gen. Microbiol. Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-12-18 Completed Date: 1980-12-18 Revised Date: 2005-01-19 |
Medline Journal Info:
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Nlm Unique ID: 0375371 Medline TA: J Gen Microbiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 39-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Bacterial
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analysis Hemagglutination Tests Immunodiffusion Neisseria meningitidis / classification*, immunology Polysaccharides, Bacterial / analysis, metabolism* Serotyping |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Polysaccharides, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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