Document Detail

Elaboration of both the group W135 and group Y capsular polysccharides by a single strain of Neisseria meningitidis.
MedLine Citation:
PMID:  6775049     Owner:  NLM     Status:  MEDLINE    
A single strain (8021) of Neisseria meningitidis, isolated from a child with disseminated meningococcal disease, was found to elaborate two serogroup-specific capsular polysaccharides-Y and W135. The original isolate as well as the progeny of ten single colony sub-isolates each agglutinated with both group Y and group W135 serogrouping antisera. The capsular polysccharide of strain 8021 contained the chemical constituents of both the W135 and Y capsular polysaccharides in a ratio of about 2.5:1. The patient responded immunologically to both capsular polysaccharides with haemagglutinating antibodies. Analysis by double diffusion in agar revealed that the capsular polysaccharide of strain 8021 contained individual molecules of group W135 and group Y capsular polysaccharides as well as a mosaic molecule containing both antigenic determinants.
B L Brandt; G B Pier; D K Goroff; P L Altieri; J M Griffiss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of general microbiology     Volume:  118     ISSN:  0022-1287     ISO Abbreviation:  J. Gen. Microbiol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2005-01-19    
Medline Journal Info:
Nlm Unique ID:  0375371     Medline TA:  J Gen Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
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MeSH Terms
Antigens, Bacterial / analysis
Hemagglutination Tests
Neisseria meningitidis / classification*,  immunology
Polysaccharides, Bacterial / analysis,  metabolism*
Reg. No./Substance:
0/Antigens, Bacterial; 0/Polysaccharides, Bacterial

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