Document Detail


Eimeria tenella infection in chickens: effect on plasma and muscle 3-methylhistidine.
MedLine Citation:
PMID:  11732670     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess muscle breakdown during avian coccidiosis, the level of the nonmetabolizable amino acid 3-methylhistidine (3MH) was determined in muscle and plasma from chickens infected with the cecal parasite Eimeria tenella. The change in 3MH level during infection was determined in birds, each inoculated with 0 to 200,000 sporulated oocysts. The effect of levels of parasitism was evaluated at 6 d postinoculation. The 3MH levels of plasma and muscle were determined by HPLC after derivatization with fluorescamine. Weight gains, packed cell volumes, and gross lesion scores were also determined. E. tenella infected birds with lesion scores of 3 or 4 had significantly elevated plasma and muscle 3MH, whereas infected birds with lesion scores of 0, 1, or 2 did not have elevated plasma and muscle 3MH; however, there was a linear inverse relationship between weight gain and both plasma and muscle 3MH. The results suggested that muscle breakdown, as assessed by plasma and muscle levels of 3MH, was elevated during the acute stage of E. tenella infection and was most likely associated with anorexia caused by infection. However, the correlation of 3MH levels with severity of infection was not as strong as that previously observed for E. acervulina infection, most likely due to the differences in pathology caused by the two species.
Authors:
R H Fetterer; P C Allen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  80     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-04     Completed Date:  2002-04-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1549-53     Citation Subset:  IM    
Affiliation:
Parasite Biology, Epidemiology and Systematics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Henry A. Wallace Beltsville Agricultural Research Center, Beltsville, Maryland, USA. rfetterer@ANRI.barc.usda.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens*
Chromatography, High Pressure Liquid
Coccidiosis / blood,  metabolism,  veterinary*
Eimeria tenella*
Male
Methylhistidines / analysis*,  blood*
Muscle, Skeletal / chemistry*
Poultry Diseases / blood,  metabolism*
Weight Gain
Chemical
Reg. No./Substance:
0/Methylhistidines; 368-16-1/3-methylhistidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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