Document Detail

"Eight drugs in one day" chemotherapy in a nonfamilial bilateral retinoblastoma with recurrent cerebrospinal fluid metastases.
MedLine Citation:
PMID:  9842651     Owner:  NLM     Status:  MEDLINE    
A case of bilateral retinoblastoma with recurrent cerebrospinal fluid (CSF) metastases is presented. The patient underwent left eye enucleation and received external beam radiotherapy to the right eye. A sequential combination chemotherapy, including cyclophosphamide, vincristine, carboplatin, and etoposide with intrathecal drug administration, was then adopted. During treatment a relapse within the central nervous system (CNS) occurred. The "8-in-1-day" chemotherapy, used in our department in medulloblastoma patients with CSF involvement was then considered. The patient received 8 total courses, each with intrathecal drug administration. No toxicity was experienced. The patient is alive and free from CSF metastases after a period of 48 months and has been in continuous complete remission (CCR) for 41 months. The authors conclude that the use of the "8-in-1" regimen is feasible and can be used in retinoblastoma patients with recurrent CSF metastases.
A Sandri; L Besenzon; A Acquaviva; C Marino; L Cordero di Montezemolo; E Madon
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  15     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  557-61     Citation Subset:  IM    
Department of Paediatric Oncology, University of Turin, Italy.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Central Nervous System Neoplasms / drug therapy*,  secondary
Cerebrospinal Fluid
Retinal Neoplasms / drug therapy*,  pathology
Retinoblastoma / drug therapy*,  pathology

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