| "Eight drugs in one day" chemotherapy in a nonfamilial bilateral retinoblastoma with recurrent cerebrospinal fluid metastases. | |
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MedLine Citation:
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PMID: 9842651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of bilateral retinoblastoma with recurrent cerebrospinal fluid (CSF) metastases is presented. The patient underwent left eye enucleation and received external beam radiotherapy to the right eye. A sequential combination chemotherapy, including cyclophosphamide, vincristine, carboplatin, and etoposide with intrathecal drug administration, was then adopted. During treatment a relapse within the central nervous system (CNS) occurred. The "8-in-1-day" chemotherapy, used in our department in medulloblastoma patients with CSF involvement was then considered. The patient received 8 total courses, each with intrathecal drug administration. No toxicity was experienced. The patient is alive and free from CSF metastases after a period of 48 months and has been in continuous complete remission (CCR) for 41 months. The authors conclude that the use of the "8-in-1" regimen is feasible and can be used in retinoblastoma patients with recurrent CSF metastases. |
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Authors:
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A Sandri; L Besenzon; A Acquaviva; C Marino; L Cordero di Montezemolo; E Madon |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: 15 ISSN: 0888-0018 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 1998 Nov-Dec |
Date Detail:
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Created Date: 1999-02-16 Completed Date: 1999-02-16 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 557-61 Citation Subset: IM |
Affiliation:
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Department of Paediatric Oncology, University of Turin, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use* Central Nervous System Neoplasms / drug therapy*, secondary Cerebrospinal Fluid Female Humans Infant Retinal Neoplasms / drug therapy*, pathology Retinoblastoma / drug therapy*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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