Document Detail

Eight-arm maze performance, neophobia, and hippocampal cholinergic alterations after prenatal oxazepam in mice.
MedLine Citation:
PMID:  1422858     Owner:  NLM     Status:  MEDLINE    
Outbred CD-1 mice were exposed to oxazepam (15 mg/kg PO twice/day) on days 12-16 of fetal life, i.e., at a critical ontogenetic stage of Type II benzodiazepine (BDZ) receptor increase, and fostered at birth to untreated dams. At adulthood, radial arm maze performance, activity-habituation test in an open-field arena (either single 15-min test or three 5-min sessions at 24-h intervals), approach to a novel stimulus object, and amphetamine or scopolamine effects thereon were assessed in male progeny. Overall, the oxazepam exposed (OX) mice were much less efficient in the radial arm maze task than the vehicle exposed (VEH) animals. Pre-test scopolamine injection, but not amphetamine, significantly impaired the arm maze performance of OX mice when compared with the corresponding VEH-scopolamine animals. In separate nonlearned behavioral tasks, prenatal oxazepam did not affect either baseline activity levels in the open field or the response to the amphetamine and the scopolamine challenge, while it considerably increased the latency of first approach to a novel object and produced a deficit of habituation in the course of the subsequent exploratory period. Concomitant investigation at the neurochemical level showed that the adult OX animals had a significant increase in both Bmax and in the affinity (Kd) of cholinergic muscarinic receptors in the hippocampal formation when compared to the vehicle-exposed controls.
G Laviola; C G Pick; J Yanai; E Alleva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  29     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-15     Completed Date:  1992-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-16     Citation Subset:  IM    
Section of Behavioral Pathophysiology, Istituto Superiore di Sanitá, Roma, Italy.
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MeSH Terms
Amphetamine / pharmacology
Anxiety / psychology*
Behavior, Animal / drug effects
Dose-Response Relationship, Drug
Exploratory Behavior / drug effects*
Hippocampus / drug effects*
Learning / drug effects
Motor Activity / drug effects
Nociceptors / drug effects
Oxazepam / pharmacology*
Parasympathetic Nervous System / drug effects*
Prenatal Exposure Delayed Effects
Reaction Time / drug effects
Receptors, Muscarinic / drug effects
Scopolamine / pharmacology
Grant Support
Reg. No./Substance:
0/Receptors, Muscarinic; 300-62-9/Amphetamine; 51-34-3/Scopolamine; 604-75-1/Oxazepam

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