| Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. | |
| | |
MedLine Citation:
|
PMID: 20861209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the effects of eicosapentaenoic acid (EPA) on prevention (P) and reversal (R) of high saturated-fat (HF) diet-induced obesity and glucose-insulin homeostasis. Male C57BL/6J mice were fed low-fat (LF; 10% energy from fat), HF (45% energy from fat), or a HF-EPA-P (45% energy from fat; 36 g/kg EPA) diet for 11 wk. A 4th group was initially fed HF for 6 wk followed by the HF-EPA-R diet for 5 wk. As expected, mice fed the HF diet developed obesity and glucose intolerance. In contrast, mice fed the HF-EPA-P diet maintained normal glucose tolerance despite weight gain compared with the LF group. Whereas the HF group developed hyperglycemia and hyperinsulinemia, both HF-EPA groups (P and R) exhibited normal glycemia and insulinemia. Further, plasma adiponectin concentration was lower in the HF group but was comparable in the LF and HF-EPA groups, suggesting a role of EPA in preventing and improving insulin resistance induced by HF feeding. Further analysis of adipose tissue adipokine levels and proteomic studies in cultured adipocytes indicated that dietary EPA supplementation of HF diets was associated with reduced adipose inflammation and lipogenesis and elevated markers of fatty acid oxidation. In C57BL/6J mice, EPA minimized saturated fat-induced insulin resistance and this is in part mediated by its effects on fatty acid oxidation and inflammation. |
| | |
Authors:
|
Nishan S Kalupahana; Kate Claycombe; Shelley J Newman; Taryn Stewart; Nalin Siriwardhana; Nirupa Matthan; Alice H Lichtenstein; Naima Moustaid-Moussa |
Related Documents
:
|
7742079 - Long-term, high-fat-sucrose diet alters rat femoral neck and vertebral morphology, bone... 2780839 - Diabetes and a high-fat/low-carbohydrate diet enhance the acceptability of oil emulsion... 20975259 - High-fat feeding influences the endocrine responses of pubertal rats to an acute stress. 6842299 - Effect of early nutrition on serum cholesterol levels in adult rats challenged with hig... 18492779 - Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-re... 20410199 - Adaptative nitric oxide overproduction in perivascular adipose tissue during early diet... 22060779 - Frozen storage of bologna sausages as a function of fat content and of levels of added ... 21852149 - Epicardial adipose tissue: emerging physiological, pathophysiological and clinical feat... 9989309 - The relation of hostility to lipids and lipoproteins in women: evidence for the role of... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-09-22 |
Journal Detail:
|
Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-21 Completed Date: 2010-11-09 Revised Date: 2011-03-10 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 1915-22 Citation Subset: IM |
Affiliation:
|
Department of Animal Science, Obesity Research Center, University of Tennessee, Knoxville, TN 37996, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3T3-L1 Cells Adipokines / metabolism Adiponectin / blood Adipose Tissue / metabolism* Animals Biological Markers / blood, metabolism Body Weight Dietary Fats / adverse effects* Eicosapentaenoic Acid / administration & dosage* Fatty Liver / pathology, prevention & control Gene Expression Regulation Glucose Intolerance / blood, prevention & control* Hyperglycemia / blood, prevention & control Hyperinsulinism / blood, prevention & control Inflammation Mediators / blood, metabolism* Insulin Resistance* Lipid Metabolism Lipogenesis Male Mice Mice, Inbred C57BL Obesity / blood, metabolism, pathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Adipokines; 0/Adiponectin; 0/Biological Markers; 0/Dietary Fats; 0/Inflammation Mediators; 1553-41-9/Eicosapentaenoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort.
Next Document: Polyphenols and Phytic Acid Contribute to the Low Iron Bioavailability from Common Beans in Young Wo...