Document Detail


Eicosanoids and isoeicosanoids: indices of cellular function and oxidant stress.
MedLine Citation:
PMID:  9478043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arachidonic acid (AA) is an unsaturated fatty acid constituent of the phospholipid domain of cell membranes. It is subject to release via mobilization of phospholipases, particularly a cytoplasmic phospholipase A2. Thereafter, it may be metabolized by at least two cyclooxygenase (COX) isoforms to prostaglandins and related compounds, via lipoxygenases to leukotrienes and via p450-catalyzed metabolism to epoxyeicosatrienoic acids. Collectively, these bioactive lipids are termed eicosanoids. All of these lipids express potent bioactivity in vitro. Clinical studies have already demonstrated the importance of COX and lipoxygenase (LOX) products in human disease. The generation of models of COX, LOX and prostaglandin receptor gene inactivation is likely to broaden our insight into the importance of these compounds in vivo. Crystallization of the biosynthetic enzymes is likely to facilitate the development of highly specific inhibitors, as is the case already for COX-2. AA possesses intrinsic biological properties. It is also subject to free radical attack, generating isomeric eicosanoid species, the isoeicosanoids. These compounds may also express biological activity in vitro, although their importance in vivo is unclear. Development of specific assays for these compounds in urine suggests their utility as noninvasive indices of oxidant stress in vivo.
Authors:
M P Reilly; J A Lawson; G A FitzGerald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  128     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-18     Completed Date:  1998-03-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  434S-438S     Citation Subset:  IM    
Affiliation:
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Dinoprost / analysis,  metabolism
Eicosanoids / chemistry,  physiology*
Humans
Isomerism
Oxidative Stress / physiology*
Grant Support
ID/Acronym/Agency:
HL 54500/HL/NHLBI NIH HHS; HL 57847/HL/NHLBI NIH HHS; M01RR00040/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Eicosanoids; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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