Document Detail

Eicosanoids influence insect susceptibility to nucleopolyhedroviruses.
MedLine Citation:
PMID:  19761772     Owner:  NLM     Status:  MEDLINE    
Nine pharmaceutical inhibitors of eicosanoid biosynthesis (e.g., bromophenacyl bromide, clotrimazole, diclofenamic acid, esculetin, flufenamic acid, indomethacin, nimesulide, sulindac, tolfenamic acid) that increased the susceptibility of the gypsy moth, Lymantria dispar (L.), to the nucleopolyhedrovirus LdMNPV were tested against the beet armyworm Spodoptera exigua (H??bner), the corn earworm Helicoverpa zea (Boddie) and the fall armyworm Spodoptera frugiperda (J.E. Smith) and their respective NPVs to determine whether these compounds also alter the susceptibility of these insects. The susceptibility of the beet armyworm was increased by six inhibitors (bromophenacyl bromide, clotrimazole, diclofenic acid, esculetin, flufenamic acid, nimesulide). The susceptibility of the fall armyworm was increased by seven inhibitors, (bromophenacyl bromide, diclofenamic acid, esculetin, indomethacin, nimesulide, sulindac, tolfenamic acid), whereas the susceptibility of the corn earworm was increased by only one inhibitor (sulindac). The influence of the cyclooxygenase inhibitor, indomethacin was expressed in a concentration-related manner in beet armyworms. We infer from these findings that eicosanoids, including prostaglandins and lipoxygenase products, act in insect anti-viral defenses.
David W Stanley; Martin Shapiro
Publication Detail:
Type:  Journal Article     Date:  2009-09-15
Journal Detail:
Title:  Journal of invertebrate pathology     Volume:  102     ISSN:  1096-0805     ISO Abbreviation:  J. Invertebr. Pathol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014067     Medline TA:  J Invertebr Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
USDA/Agricultural Research Service, Biological Control of Insects Research Laboratory, 1503 S. Providence Road, Columbia MO 65203, USA.
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MeSH Terms
Cyclooxygenase Inhibitors / pharmacology*
Eicosanoids / antagonists & inhibitors,  physiology*
Immunity, Innate / drug effects
Moths / drug effects,  immunology,  virology*
Nucleopolyhedrovirus / pathogenicity*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Eicosanoids

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