| Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment. | |
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MedLine Citation:
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PMID: 8317305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of 14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxy-eicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score. |
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Authors:
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F J Zijlstra; A P van Dijk; R J Ouwendijk; I C van Riemsdijk-Overbeeke; J H Wilson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Agents and actions Volume: 38 Spec No ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1993 |
Date Detail:
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Created Date: 1993-07-29 Completed Date: 1993-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: C122-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminosalicylic Acids
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pharmacology* Colitis, Ulcerative / drug therapy, metabolism* Eicosanoids / biosynthesis* Female Humans Hydroxyeicosatetraenoic Acids / biosynthesis Intestinal Mucosa / drug effects, metabolism* Leukotrienes / biosynthesis Male Mesalamine Prostaglandins / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Aminosalicylic Acids; 0/Eicosanoids; 0/Hydroxyeicosatetraenoic Acids; 0/Leukotrienes; 0/Prostaglandins; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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