| Eicosanoid-mediated increase in glucose and lactate output as well as decrease and redistribution of flow by complement-activated rat serum in perfused rat liver. | |
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MedLine Citation:
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PMID: 2007411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat serum, in which the complement system had been activated by incubation with zymosan, increased the glucose and lactate output, and reduced and redistributed the flow in isolated perfused rat liver clearly more than the control serum. Heat inactivation of the rat serum prior to zymosan incubation abolished this difference. Metabolic and hemodynamic alterations caused by the activated serum were dose dependent. They were almost completely inhibited by the cyclooxygenase inhibitor indomethacin and by the thromboxane antagonist 4-[2-(4-chlorobenzesulfonamide)-ethyl]-benzene-acetic acid (BM 13505), but clearly less efficiently by the 5'-lipoxygenase inhibitor nordihydroguaiaretic acid and the leukotriene antagonist N-(3-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-4-chlorine-6-meth yl- phenyl)-1H-tetrazole-5-carboxamide sodium salt (CGP 35949 B). Control serum and to a much larger extent complement-activated serum, caused an overflow of thromboxane B2 and prostaglandin F2 alpha into the hepatic vein. It is concluded that the activated complement system of rat serum can influence liver metabolism and hemodynamics via release from nonparenchymal liver cells of thromboxane and prostaglandins, the latter of which can in turn act on the parenchymal cells. |
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Authors:
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W Muschol; G P Püschel; M Hülsmann; K Jungermann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 196 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-04-26 Completed Date: 1991-04-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY |
Other Details:
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Languages: eng Pagination: 525-30 Citation Subset: IM |
Affiliation:
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Institut für Biochemie, Georg-August-Universität Göttingen, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology Complement Activation / drug effects* Complement Inactivator Proteins / pharmacology Complement Pathway, Alternative / physiology Dinoprost / antagonists & inhibitors, blood Eicosanoids / biosynthesis*, pharmacology Glucose / metabolism* Hemodynamics / drug effects Hot Temperature Lactates / metabolism* Lactic Acid Liver / metabolism* Male Rats Rats, Inbred Strains Thromboxane B2 / antagonists & inhibitors, blood Zymosan / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Complement Inactivator Proteins; 0/Eicosanoids; 0/Lactates; 50-21-5/Lactic Acid; 50-99-7/Glucose; 54397-85-2/Thromboxane B2; 551-11-1/Dinoprost; 9010-72-4/Zymosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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