| Egg white as a blood coagulation surrogate. | |
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MedLine Citation:
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PMID: 20649242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Egg white, a protein-containing solution, is characterized as a blood coagulation surrogate for the acoustical and thermal evaluation of therapeutic ultrasound, especially high intensity focused ultrasound (HIFU) devices. Physical properties, including coagulation temperature, frequency dependent attenuation, sound speed, viscosity, and thermal properties, were measured as a function of temperature (20-95 degrees C). Thermal coagulation and attenuation (5-12 and 1 MHz) of cow blood, pig blood, and human blood also were assessed and compared with egg white. For a 30 s thermal exposure, both egg white and blood samples (3 mm thickness) started to denature at 65 degrees C and coagulate into an elastic gel at 85 degrees C. The attenuation of egg white was found to be similar to that of the blood samples, having values of 0.23f(1.09), 1.58f(0.61), and 2.7f(0.5) dB/cm at 20, 75, and 95 degrees C, respectively. This significant attenuation increase with temperature was determined to be caused mainly by bubble cavity formation. The other temperature-dependent parameters are also similar to the reported values for blood. These properties make egg white a potentially useful bench testing tool for the safety and efficacy evaluation of therapeutic ultrasound devices. |
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Authors:
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Yunbo Liu; Subha Maruvada; Bruce A Herman; Gerald R Harris |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 128 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 480-9 Citation Subset: IM |
Affiliation:
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Center for Devices and Radiological Health, Food and Drug Administration, Building 62, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA. yxl@cdrh.fda.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation* Blood Coagulation Factors / chemistry* Cattle Egg Proteins / chemistry* Elasticity High-Intensity Focused Ultrasound Ablation / instrumentation* Humans Motion Phantoms, Imaging* Protein Denaturation Sound Swine Temperature Time Factors Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 0/Egg Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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