Document Detail

Egg allergy in childhood: an update.
MedLine Citation:
PMID:  19369862     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Allergy to hen's egg is common in infancy and childhood. The management of egg allergy involves dietary avoidance of egg-containing foods, implementation of anaphylaxis precautions and ongoing monitoring for tolerance development. In this article, we review the recent literature regarding the immunology, clinical presentation, diagnosis, management and natural history of egg allergy. RECENT FINDINGS: Retrospective studies suggest that most egg-allergic children will become tolerant over time. Regular ingestion of small quantities of cooked egg in baked products is often well tolerated and may hasten tolerance development. Influenza vaccination of egg-allergic patients remains controversial, and immunization of patients with previous significant reactions or anaphylaxis to egg is currently not recommended. In recent years, there has been increasing success in clinical trials of specific oral tolerance induction to egg, but concerns regarding the safety and long-term efficacy still preclude the use of oral immunotherapy in clinical practice. SUMMARY: Egg allergy generally has a good prognosis. Despite recent advances in oral immunotherapy trials, the treatment of egg allergy currently relies on avoidance of egg-containing foods until tolerance has developed. It remains unclear whether the ongoing low-dose exposure to egg proteins in cooked foods improves the natural history of egg allergy.
Dean Tey; Ralf G Heine
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  9     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia.
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MeSH Terms
Allergens / adverse effects,  immunology
Child, Preschool
Clinical Trials as Topic
Dermatitis, Atopic / diagnosis,  immunology,  therapy
Egg Hypersensitivity / diagnosis*,  immunology*,  therapy
Egg Proteins / adverse effects*,  immunology
Eggs / adverse effects*
Immune Tolerance
Immunoglobulin E / blood
Influenza Vaccines / administration & dosage
Risk Factors
Skin Tests
Reg. No./Substance:
0/Allergens; 0/Egg Proteins; 0/Influenza Vaccines; 37341-29-0/Immunoglobulin E

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