Document Detail

[Effort-reward imbalance at work and depression: current research evidence].
MedLine Citation:
PMID:  23135155     Owner:  NLM     Status:  MEDLINE    
In view of highly prevalent stressful conditions in modern working life, in particular increasing work pressure and job insecurity, it is of interest to know whether specific constellations of an adverse psychosocial work environment increase the risk of depressive disorder among employed people. This contribution gives a short overview of current research evidence based on an internationally established work stress model of effort-reward imbalance. Taken together, results from seven prospective epidemiological investigations demonstrate a two-fold elevated relative risk of incident depressive disorder over a mean observation period of 2.7 years among exposed versus non-exposed employees. Additional findings from experimental and quasi-experimental studies point to robust associations of effort-reward imbalance at work with proinflammatory cytokines and markers of reduced immune competence. These latter markers may indicate potential psychobiological pathways. In conclusion, incorporating this new knowledge into medical treatment and preventive efforts seems well justified.
J Siegrist
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Der Nervenarzt     Volume:  84     ISSN:  1433-0407     ISO Abbreviation:  Nervenarzt     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-06-26     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0400773     Medline TA:  Nervenarzt     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  33-7     Citation Subset:  IM    
Vernacular Title:
Berufliche Gratifikationskrisen und depressive Störungen : Aktuelle Forschungsevidenz.
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MeSH Terms
Arousal / physiology
Brain / physiopathology
Burnout, Professional / diagnosis*,  physiopathology,  psychology*
Cytokines / blood
Depressive Disorder / diagnosis*,  physiopathology,  psychology*
Hypothalamo-Hypophyseal System / physiopathology
Immune Tolerance / immunology
Immunity, Cellular / immunology
Immunocompetence / immunology
Inflammation Mediators / blood
Job Satisfaction*
Longitudinal Studies
Models, Psychological
Neuroimmunomodulation / physiology
Pituitary-Adrenal System / physiopathology
Social Environment
Stress, Psychological / complications,  physiopathology
Sympathetic Nervous System / physiopathology
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators

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