Document Detail

Efficient synthesis of arrays of amino acid derived Ugi products with subsequent amidation.
MedLine Citation:
PMID:  19425617     Owner:  NLM     Status:  MEDLINE    
Several amino acid derived iminodicarboxylicacid monomethylesters have been converted into a small array of amide derivatives. Sequentially, we were using an Ugi reaction of alpha-amino acids, followed by a mild and efficient amidation. Thus we added to this well-known Ugi scaffold another dimension of diversity, thereby enhancing it is potentially use in the combinatorial and medicinal chemistry of multi component reactions (MCRs) and drug discovery. Synthesis of an exemplary array and pharmacophore features are discussed.
Wei Wang; Alexander Dömling
Related Documents :
7380607 - Chemical modification of methionines of ribonuclease a with o-benzoquinone.
19695327 - Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of do...
22188367 - Hydrogen-bubble propelled zinc-based microrockets in strongly acidic media.
18558337 - Identification of novel derivative of helvolic acid from metarhizium anisopliae grown i...
15644987 - Valproic acid inhibits corticotropin-releasing factor synthesis and release from the ra...
7918867 - Release and steroidogenic actions of polyunsaturated fatty acids in the goldfish testis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of combinatorial chemistry     Volume:  11     ISSN:  1520-4774     ISO Abbreviation:  J Comb Chem     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886263     Medline TA:  J Comb Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amides / chemical synthesis*,  chemistry
Amino Acids / chemical synthesis,  chemistry*
Combinatorial Chemistry Techniques / methods*
Cyanides / chemical synthesis,  chemistry*
Esters / chemical synthesis,  chemistry*
Models, Molecular
Molecular Structure
Reg. No./Substance:
0/Amides; 0/Amino Acids; 0/Cyanides; 0/Esters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Catalase vs peroxidase activity of a manganese(II) compound: identification of a Mn(III)-(mu-O)(2)-M...
Next Document:  In-Gel (18)O Labeling for Improved Identification of Proteins from 2-DE Gel Spots in Comparative Pro...