Document Detail

Efficient synthesis of arrays of amino acid derived Ugi products with subsequent amidation.
MedLine Citation:
PMID:  19425617     Owner:  NLM     Status:  MEDLINE    
Several amino acid derived iminodicarboxylicacid monomethylesters have been converted into a small array of amide derivatives. Sequentially, we were using an Ugi reaction of alpha-amino acids, followed by a mild and efficient amidation. Thus we added to this well-known Ugi scaffold another dimension of diversity, thereby enhancing it is potentially use in the combinatorial and medicinal chemistry of multi component reactions (MCRs) and drug discovery. Synthesis of an exemplary array and pharmacophore features are discussed.
Wei Wang; Alexander Dömling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of combinatorial chemistry     Volume:  11     ISSN:  1520-4774     ISO Abbreviation:  J Comb Chem     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886263     Medline TA:  J Comb Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261, USA.
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MeSH Terms
Amides / chemical synthesis*,  chemistry
Amino Acids / chemical synthesis,  chemistry*
Combinatorial Chemistry Techniques / methods*
Cyanides / chemical synthesis,  chemistry*
Esters / chemical synthesis,  chemistry*
Models, Molecular
Molecular Structure
Reg. No./Substance:
0/Amides; 0/Amino Acids; 0/Cyanides; 0/Esters

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