| Efficient removal of albumin-bound furancarboxylic acid, an inhibitor of erythropoiesis, by continuous ambulatory peritoneal dialysis. | |
| | |
MedLine Citation:
|
PMID: 2077405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid, which cannot be removed by conventional hemodialysis due to its strong albumin binding, was found to be efficiently removed by continuous ambulatory peritoneal dialysis (CAPD), resulting in a lower serum level in uremic patients on CAPD than in those on hemodialysis. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid was demonstrated in vitro to inhibit erythroid colony formation. The anemia in patients on CAPD was significantly less severe than in those on hemodialysis. These results suggest that the efficient removal by CAPD of 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, an inhibitor of erythropoiesis, is related to an improvement of anemia in patients on CAPD. |
| | |
Authors:
|
T Niwa; T Yazawa; T Kodama; Y Uehara; K Maeda; K Yamada |
Related Documents
:
|
17951725 - Acrylodan-labeled intestinal fatty acid-binding protein to measure concentrations of un... 3105045 - Binding characteristics of human serum amyloid p component. 7364935 - Sex steroid modulation of fatty acid utilization and fatty acid binding protein concent... 133045 - Studies of tryptophan and albumin metabolism in a patient with carcinoid syndrome, pell... 11375435 - Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an ada... 16960355 - Distribution and metabolism of dihomo-gamma-linolenic acid (dgla, 20:3n-6) by oral supp... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nephron Volume: 56 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1990 |
Date Detail:
|
Created Date: 1991-04-22 Completed Date: 1991-04-22 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 241-5 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Nagoya University Branch Hospital, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Albumins / metabolism* Anemia / metabolism Chromatography, High Pressure Liquid Colony-Forming Units Assay Erythropoiesis / drug effects* Female Furans / blood, metabolism*, pharmacology Humans Kidney / metabolism Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* Propionic Acids / blood, metabolism*, pharmacology Uremia / metabolism, therapy |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/Furans; 0/Propionic Acids; 86879-39-2/3-carboxy-4-methyl-5-propyl-2-furanpropionic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protein-induced changes in kidney function depend on the time of administration but not on the dieta...
Next Document: Production of methylguanidine from creatinine in normal rats and rats with renal failure.