| Efficient myogenic reprogramming of adult white fat stem cells and bone marrow stem cells by freshly isolated skeletal muscle fibers. | |
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MedLine Citation:
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PMID: 22061041 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Stem cells that can be directed to differentiate into specific cell types offer the prospect of a renewable source of replacement cells to treat diseases. This study evaluates the reprogramming of 2 readily available stem cell populations into skeletal muscle. We show for the first time that freshly isolated muscle fibers reprogram bone marrow or white fat stem cells far more efficiently than muscle cell lines. In addition, we show that the ability of muscle fibers to reprogram stem cells can be almost doubled through the use of chromatin remodeling reagents such as trichostatin A. This novel approach permits the generation of myogenic cells that could be used to treat a range of muscle-wasting diseases. |
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Authors:
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Henry Collins-Hooper; Graham Luke; Mark Cranfield; William R Otto; Steve Ray; Ketan Patel |
Publication Detail:
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Type: Journal Article Date: 2011-08-24 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 158 ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 334-43 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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School Biological Sciences, University of Reading, Reading, UK. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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