Document Detail

Efficient and mild microwave-assisted stepwise functionalization of naphthalenediimide with alpha-amino acids.
MedLine Citation:
PMID:  16930065     Owner:  NLM     Status:  MEDLINE    
Microwave dielectric heating proved to be an efficient method for the one-pot and stepwise syntheses of symmetrical and unsymmetrical naphthalenediimide derivatives of alpha-amino acids. Acid-labile side chain protecting groups are stable under the reaction conditions; protection of the alpha-carboxylic group is not required. The stepwise condensation of different amino acids resulted in high yields of unsymmetrical naphthalenediimides. The reaction proceeds without racemization and is essentially quantitative.
Paolo Pengo; G Dan Pantos; Sijbren Otto; Jeremy K M Sanders
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  71     ISSN:  0022-3263     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2007-06-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7063-6     Citation Subset:  IM    
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
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MeSH Terms
Amino Acids / chemical synthesis*,  chemistry
Chemistry, Organic / methods*
Crystallography, X-Ray
Magnetic Resonance Spectroscopy
Molecular Structure
Phenanthrolines / chemistry*
Reg. No./Substance:
0/Amino Acids; 0/Imides; 0/Naphthalenes; 0/Phenanthrolines; 22291-04-9/naphthalenediimide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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