Document Detail

Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions.
MedLine Citation:
PMID:  20830335     Owner:  NLM     Status:  MEDLINE    
We report a mild and environmentally benign method for the synthesis of tertiary amines using alcohols as the alkylating reagents. Not only secondary amines such as piperazines but also amino acids and amino alcohols can be N-alkylated selectively. For N,O-benzyl protected amino alcohols, both N,O-de-benzylation and N-methylation were achieved in one-pot.
Chu-Pei Xu; Zhen-Hua Xiao; Bi-Qin Zhuo; Yu-Huang Wang; Pei-Qiang Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-09
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  46     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  7834-6     Citation Subset:  IM    
Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry & Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
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MeSH Terms
Alcohols / chemistry*
Alkylating Agents / chemistry*
Amines / chemistry*
Amino Acids / chemistry*
Green Chemistry Technology / methods*
Substrate Specificity
Reg. No./Substance:
0/Alcohols; 0/Alkylating Agents; 0/Amines; 0/Amino Acids

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