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Efficient brain lesion segmentation using multi-modality tissue-based feature selection and support vector machines.
MedLine Citation:
PMID:  23303595     Owner:  NLM     Status:  Publisher    
Support vector machines (SVM) are machine learning techniques that have been used for segmentation and classification of medical images, including segmentation of white matter hyper-intensities (WMH). Current approaches using SVM for WMH segmentation extract features from the brain and classify these followed by complex post-processing steps to remove false positives. The method presented in this paper combines advanced pre-processing, tissue-based feature selection and SVM classification to obtain efficient and accurate WMH segmentation. Features from 125 patients, generated from up to four MR modalities [T1-w, T2-w, proton-density and fluid attenuated inversion recovery(FLAIR)], differing neighbourhood sizes and the use of multi-scale features were compared. We found that although using all four modalities gave the best overall classification (average Dice scores of 0.54  ±  0.12, 0.72  ±  0.06 and 0.82  ±  0.06 respectively for small, moderate and severe lesion loads); this was not significantly different (p = 0.50) from using just T1-w and FLAIR sequences (Dice scores of 0.52  ±  0.13, 0.71  ±  0.08 and 0.81  ±  0.07). Furthermore, there was a negligible difference between using 5 × 5 × 5 and 3 × 3 × 3 features (p = 0.93). Finally, we show that careful consideration of features and pre-processing techniques not only saves storage space and computation time but also leads to more efficient classification, which outperforms the one based on all features with post-processing. Copyright © 2013 John Wiley & Sons, Ltd.
Jean-Baptiste Fiot; Laurent D Cohen; Parnesh Raniga; Jurgen Fripp
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  International journal for numerical methods in biomedical engineering     Volume:  -     ISSN:  2040-7947     ISO Abbreviation:  Int j numer method biomed eng     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101530293     Medline TA:  Int j numer method biomed eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
CEREMADE, UMR 7534 CNRS Université Paris Dauphine, France; CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre - BioMedIA, Royal Brisbane and Women's Hospital, Herston, Qld, Australia.
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