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Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.
MedLine Citation:
PMID:  23459418     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A concise and efficient synthetic approach to producing a novel non-cyclic nucleotide EPAC antagonist ESI-09 and its new analogs is reported. Key features of the synthesis include a mild and reliable one-pot procedure for an isoxazole synthon, as well as a modified one-pot protocol for the cyanomethyl ketone key intermediate. The synthesis requires inexpensive starting materials and only three linear steps for the completion in a total yield of 53%.
Authors:
Haijun Chen; Chunyong Ding; Christopher Wild; Huiling Liu; Tianzhi Wang; Mark A White; Xiaodong Cheng; Jia Zhou
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Tetrahedron letters     Volume:  54     ISSN:  0040-4039     ISO Abbreviation:  Tetrahedron Lett.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984819R     Medline TA:  Tetrahedron Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1546-1549     Citation Subset:  -    
Affiliation:
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
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