Document Detail


Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.
MedLine Citation:
PMID:  23459418     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A concise and efficient synthetic approach to producing a novel non-cyclic nucleotide EPAC antagonist ESI-09 and its new analogs is reported. Key features of the synthesis include a mild and reliable one-pot procedure for an isoxazole synthon, as well as a modified one-pot protocol for the cyanomethyl ketone key intermediate. The synthesis requires inexpensive starting materials and only three linear steps for the completion in a total yield of 53%.
Authors:
Haijun Chen; Chunyong Ding; Christopher Wild; Huiling Liu; Tianzhi Wang; Mark A White; Xiaodong Cheng; Jia Zhou
Related Documents :
23656398 - Mechanism and kinetics of the atmospheric oxidative degradation of dimethylphenol isome...
24060538 - Efficient synthesis of pure monotosylated beta-cyclodextrin and its dimers.
23908558 - Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1h-pyrrolo-[3,2h]isoquin...
23411078 - Extending the versatility of the hemetsberger-knittel indole synthesis through microwav...
10187908 - Steady-state kinetics of combined oxidation of hydroquinone and o-dianisidine by hydrog...
3003078 - Inhibition of erythrocyte superoxide dismutase by diethyldithiocarbamate also results i...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Tetrahedron letters     Volume:  54     ISSN:  0040-4039     ISO Abbreviation:  Tetrahedron Lett.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984819R     Medline TA:  Tetrahedron Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1546-1549     Citation Subset:  -    
Affiliation:
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bifurcation theory and cardiac arrhythmias.
Next Document:  A comparison of participation and performance in age-group finishers competing in and qualifying for...