Document Detail


Efficient Diastereoselective Synthesis of (2R,3R,4R)-2-Amino-3-hydroxy-4,5-dimethylhexanoic Acid, the Lactone Linkage Unit of Homophymine A.
MedLine Citation:
PMID:  23370199     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
For the total synthesis of novel cyclodepsipeptide homophymine A, (2R,3R,4R)-2-amino-3-hydroxy-4,5-dimethylhexanoic acid was successfully synthesized by Evans' asymmetric alkylation and the anti-selective asymmetric hydrogenation of a chiral α-amino-β-keto ester as the key steps.
Authors:
Junpei Ohtaka; Akinari Hamajima; Tetsuhiro Nemoto; Yasumasa Hamada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  61     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  245-50     Citation Subset:  IM    
Affiliation:
Graduate School of Pharmaceutical Sciences, Chiba University.
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