| Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae. | |
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MedLine Citation:
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PMID: 18774563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To highlight the efficiency of intrauterine device (IUD) guidance during hysteroscopic adhesiolysis for severe intrauterine adhesions. DESIGN: A prospective, randomized trial. SETTING: Private tertiary and referral infertility clinic. PATIENT(S): Seventy-one subfertile patients who underwent hysteroscopic treatment of intrauterine synechiae or adhesions. INTERVENTION(S): Thirty-six women in group 1 were initially examined by laparoscopy-hysteroscopy at first look, and an IUD was inserted during hysteroscopic adhesiolysis. The adhesions were further lysed by the guidance of IUD during the second-look office hysteroscopy, 1 week later. Patients were prescribed 2 months of estrogen as well as P therapy, and the IUD was removed by the end of this period. The uterine cavity was evaluated, and adhesions were further lysed by a third-look office hysteroscopy, 1 week after the removal of IUD. Thirty-five women in group 2 were similarly examined by first-look office hysteroscopy, and an IUD was inserted during hysteroscopic adhesiolysis. These patients did not undergo early intervention of office hysteroscopy, 1 week after the first procedure. They also used 2 months of estrogen and P therapy. The IUD was removed by the end of this period, and the uterine cavity was evaluated and adhesions were further lysed during a second-look office hysteroscopy. MAIN OUTCOME MEASURE(S): Pregnancy rate and live birth rate. RESULT(S): Spontaneous pregnancy rates after treatment were 17/36 (47.2%) and 11/35 (30%), and live birth rates were 10/36 (28%) and 7/35 (20%) in groups 1 and 2, respectively. These differences between the two groups were not statistically significant. CONCLUSION(S): The method described especially for early intervention may prevent complications during the treatment of severe intrauterine adhesions and may present a secure and effective alternative for constructive clinical outcomes. |
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Authors:
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Recai Pabuccu; Gogsen Onalan; Cemil Kaya; Belgin Selam; Temel Ceyhan; Turkan Ornek; Ebru Kuzudisli |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2008-09-06 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1973-7 Citation Subset: IM |
Affiliation:
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Centrum Clinic, Ankara, Turkey. rpabuccu@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Estrogens / administration & dosage Estrogens, Conjugated (USP) / administration & dosage Female Fertilization in Vitro Humans Hysteroscopy* / adverse effects Infertility, Female / drug therapy, etiology*, pathology, surgery Intrauterine Devices* Laparoscopy* / adverse effects Live Birth Medroxyprogesterone Acetate / administration & dosage Pregnancy Pregnancy Rate Progestins / administration & dosage Prospective Studies Time Factors Tissue Adhesions Treatment Outcome Uterine Diseases / complications, drug therapy, pathology, surgery* |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Estrogens, Conjugated (USP); 0/Progestins; 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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