Document Detail


Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor.
MedLine Citation:
PMID:  23286945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of common variable immunodeficiency disorders (CVID) is based on replacement therapy using intravenous (i.v.) or subcutaneous (s.c.) immunoglobulin (Ig)G. Interindividual variation of IgG dose is common. A total of 380 CVID patients on stable IgG replacement from two prospective cohorts were analysed. An 'efficiency' index was defined as the ratio of serum IgG trough level minus IgG residual to the average weekly dose of IgG infusion. A reduced efficiency of IgG was associated independently with the i.v. route (P < 0·001) and with the presence of at least one CVID disease-related phenotype (lymphoproliferation, autoimmune cytopenia or enteropathy) (P < 0·001). High IgG efficiency was noted in patients homozygotes for the variable number tandem repeat (VNTR) 3/3 polymorphism of the neonatal Fc receptor gene [IgG Fc fragment receptor transporter alpha chain (FCGRT)] promoter, and this was particularly significant in patients treated with IVIG (P < 0.01). In a multivariate analysis, FCGRT VNTR 3/3 genotype (P = 0·008) and high serum albumin (P < 0·001) were associated independently with increased efficiency of i.v. Ig.
Authors:
V Gouilleux-Gruart; H Chapel; S Chevret; M Lucas; M Malphettes; C Fieschi; S Patel; D Boutboul; M-N Marson; L Gérard; M Lee; H Watier; E Oksenhendler;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-03-12     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  186-94     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biomarkers, Pharmacological*
Cohort Studies
Common Variable Immunodeficiency / drug therapy*,  immunology
Female
Histocompatibility Antigens Class I / genetics*
Humans
Immunoglobulins, Intravenous / administration & dosage*,  adverse effects
Injections, Subcutaneous
Male
Middle Aged
Minisatellite Repeats / genetics
Phenotype
Polymorphism, Genetic
Promoter Regions, Genetic / genetics
Prospective Studies
Receptors, Fc / genetics*
Transcriptional Activation / genetics
Treatment Outcome
Chemical
Reg. No./Substance:
0/Biomarkers, Pharmacological; 0/Fc receptor, neonatal; 0/Histocompatibility Antigens Class I; 0/Immunoglobulins, Intravenous; 0/Receptors, Fc
Investigator
Investigator/Affiliation:
L Galicier / ; J P Fermand / ; J F Viallard / ; A Jaccard / ; C Hoarau / ; Y Lebranchu / ; A Bérezné / ; L Mouthon / ; M Karmochkine / ; S Georgin-Lavialle / ; N Schleinitz / ; I Durieu / ; R Nove-Josserand / ; V Chanet / ; V Le-Moing / ; N Just / ; C Salanoubat / ; R Jaussaud / ; F Suarez / ; O Hermine / ; P Solal-Celigny / ; E Hachulla / ; L Sanhes / ; M Gardembas / ; I Pellier / ; P Tisserant / ; M Pavic / ; B Bonnotte / ; J Haroche / ; Z Amoura / ; L Alric / ; M F Thiercelin / ; L Tetu / ; D Adoue / ; P Bordigoni / ; T Perpoint / ; P Sève / ; P Rohrlich / ; J L Pasquali / ; P Soulas / ; L J Couderc / ; E Catherinot / ; P Giraud / ; A Baruchel / ; I Deleveau / ; F Chaix / ; J Donadieu / ; F Tron / ; C Larroche / ; Ap Blanc / ; A Masseau / ; M Hamidou / ; G Kanny / ; M Morisset / ; F Millot / ; O Fain / ; R Borie / ; A Perlat / ; V Martinez / ; B Bienvenu / ; P Debré / ; G Mouillot / ; I Théodorou / ; C Rabian / ; M Carmagnat / ; N Vince / ; C Bono /
Comments/Corrections

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