Document Detail


Efficiency of hit generation and structural characterization in fragment-based ligand discovery.
MedLine Citation:
PMID:  21724447     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fragment-based ligand discovery constitutes a useful strategy for the generation of high affinity ligands with suitable physico-chemical properties to serve as drug leads. There is an increasing number of generic biophysical screening strategies established with the potential for accelerating the generation of useful fragment hits. Crystal structures of these hits can subsequently be used as starting points for fragment evolution to high affinity ligands. Emerging understanding of the efficiency and operative aspects of hit generation and structural characterization in FBLD suggests that this method should be well suited for academic ligand development of chemical tools and experimental therapeutics.
Authors:
Andreas Larsson; Anna Jansson; Anders Aberg; Pär Nordlund
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Current opinion in chemical biology     Volume:  -     ISSN:  1879-0402     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9811312     Medline TA:  Curr Opin Chem Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
School of Biological Sciences, Nanyang Technological University, 61 Nanyang Drive, Singapore 639798, Singapore.
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