Document Detail

Efficiency of an external support to reduce lipid infiltration into venous grafts: in vitro evaluation.
MedLine Citation:
PMID:  8908331     Owner:  NLM     Status:  MEDLINE    
Excessive distension of venous grafts due to arterial pressure enhances the convective water transport (filtration flow) through the vessel wall, and thus might affect the infiltration of macromolecules such as lipoproteins. In this paired experimental study, filtration velocities were measured at 100 mm Hg for canine jugular veins with or without external supports of expanded polytetrafluoroethylene (ePTFE) arterial prostheses. In addition, to assess the effect of filtration velocity on lipid infiltration or uptake, canine jugular veins were wrapped over half of their lengths with ePTFE arterial prostheses and perfused with dog serum containing 3H-cholesterol at a pressure of 100 mm Hg. At 100 mm Hg, the average filtration velocity of the wrapped jugular veins was 7.9 +/- 1.3 x 10(-6) cm/s whereas the average filtration velocity of the unwrapped veins was 27.3 +/- 2.7 x 10(-6) cm/s (p < 0.005). Moreover, the unwrapped veins had a significantly higher uptake rate of labeled cholesterol than the wrapped veins (10.9 +/- 7.3 x 10(-4) cm/h and 5.0 +/- 1.6 x 10(-4) cm/h, respectively, p < 0.005). In conclusion, under arterial pressure, veins experience excessive distention, which leads to significant increases in both filtration flow and cholesterol uptake. An external wrap or support of ePTFE material protects veins from excessive distension and thus may prevent atherosclerosis in venous grafts by reducing cholesterol uptake.
X Deng; Y Marois; R Guidoin; Y Merhi; P Stroman; M W King; Y Douville
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  20     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-07     Completed Date:  1997-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1208-14     Citation Subset:  IM    
Department of Surgery, Laval University, Ste-Foy, Quebec, Canada.
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MeSH Terms
Biocompatible Materials / metabolism
Blood Vessel Prosthesis / adverse effects*,  standards
Cholesterol / metabolism*
Isotope Labeling
Jugular Veins / metabolism*,  physiology,  ultrastructure
Microscopy, Electron, Scanning
Polytetrafluoroethylene / metabolism*
Reg. No./Substance:
0/Biocompatible Materials; 10028-17-8/Tritium; 57-88-5/Cholesterol; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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