Document Detail

Efficiency of controlled topical delivery of silver sulfadiazine in infected burn wounds.
MedLine Citation:
PMID:  18431769     Owner:  NLM     Status:  MEDLINE    
The present study is designed to assess the potential benefits of controlled delivery of silver sulfadiazine from collagen scaffold (SSDM-CS) in infected deep partial thickness burn wounds in which epidermis is lost completely and the entire papillary dermis and most of the recticular layer of the dermis is lost. Infection induced by inoculating 10(7) colony forming units (cfu) of Pseudomonas aeruginosa caused significant increase in wound size (20%) till day 15, which decreased significantly from day 9 by SSDM-CS treatment, showing complete healing by day 27 (control > or = 37 days). Early subsidence of infection (<10(2) cfu, day 9) by SSDM-CS resulted in faster epidermal resurfacing and fibroplasia, whereas heavy microbial load (>10(7) cfu, day 9) in controls caused severe inflammatory cellular infiltration. Persistent infection triggered early expression of proinflammatory cytokines intereukin-6, intereukin 1-beta, and tumor necrosis factor-alpha, lasting until day 9, whereas cytokine level decreased in SSDM-CS-treated group by day 6. Infection exacerbated expression of active matrix metalloproteinases (MMPs)-2 and -9 in controls (day 15), while SSDM-CS positively modulated MMP-2 and -9 with faster decline in their levels (day 12). Inherent nature of the dressing to maintain drug level at equilibrium therapeutic concentration (51.2 microg/mL) for prolonged time (72 h), below systemic toxic limits (20 microg/dL, serum level), accelerated the magnitude and sequence of reparative events.
N Shanmugasundaram; T S Uma; T S Ramyaa Lakshmi; Mary Babu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  89     ISSN:  1552-4965     ISO Abbreviation:  -     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-26     Completed Date:  2009-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-82     Citation Subset:  IM    
Biomaterials Division, Central Leather Research Institute - TICEL Biopark, Tharamani Road, Tharamani, Chennai 600 113, Tamil Nadu, India.
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MeSH Terms
Administration, Topical
Blotting, Western
Body Weight / drug effects
Burns / complications*,  drug therapy*,  enzymology,  pathology
Collagen / metabolism
Cytokines / metabolism
Delayed-Action Preparations
Enzyme Activation / drug effects
Hexosamines / metabolism
Inflammation Mediators / metabolism
Matrix Metalloproteinases / metabolism
Rats, Wistar
Silver Sulfadiazine / administration & dosage*,  pharmacology,  therapeutic use*
Wound Healing / drug effects
Wound Infection / complications*,  drug therapy*,  enzymology,  pathology
Reg. No./Substance:
0/Cytokines; 0/Delayed-Action Preparations; 0/Hexosamines; 0/Inflammation Mediators; 22199-08-2/Silver Sulfadiazine; 9007-34-5/Collagen; EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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