| Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. | |
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MedLine Citation:
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PMID: 8726155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The best means for optimal delivery of drugs into lungs of infants with bronchopulmonary dysplasia (BPD) is uncertain. We aimed to measure radio-aerosol deposition of salbutamol by jet nebulizer and metered dose inhalers (MDI) in ventilated and non-ventilated BPD infants. In a randomized, crossover sequence, salbutamol lung deposition was measured using an MDI (2 puffs or 200 micrograms) or sidestream jet nebulizer (5 minutes of nebulization with 100 micrograms/kg) in 10 ventilated (mean birthweight, 1,101 g) and 13 non-ventilated (mean birthweight, 1,093 g) prematurely born infants. Non-ventilated infants inhaled aerosol through a face mask, connected to a nebulizer or an MDI and spacer (Aerochamber). Ventilated infants received aerosol from an MDI + MV15 Aerochamber or a nebulizer inserted in the ventilator circuit. Lung deposition by both methods was low: mean (SEM) from the MDI was 0.67 (0.17)% of the actuated dose, and from the nebulizer it was 1.74 (0.21)% and 0.28 (0.04)% of the nebulized and initial reservoir doses, respectively. Corresponding figures for the ventilated infants were 0.98 (0.19)% from the MDI and 0.95 (0.23)% and 0.22 (0.08)% from the nebulizer. In both groups, and for both methods of delivery, there was marked inter-subject variability in lung deposition and a tendency for the aerosol to be distributed to the central lung regions. |
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Authors:
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T F Fok; S Monkman; M Dolovich; S Gray; G Coates; B Paes; F Rashid; M Newhouse; H Kirpalani |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Pediatric pulmonology Volume: 21 ISSN: 8755-6863 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-11-06 Completed Date: 1996-11-06 Revised Date: 2006-03-28 |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 301-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, McMaster University Medical Centre, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Albuterol / administration & dosage*, pharmacokinetics Bronchopulmonary Dysplasia / drug therapy*, radionuclide imaging Cross-Over Studies Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Infant Infant, Newborn Lung / radionuclide imaging Male Nebulizers and Vaporizers* Oxygen Inhalation Therapy |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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