Document Detail

Efficiency of Calamintha officinalis essential oil as preservative in two topical product types.
MedLine Citation:
PMID:  15239707     Owner:  NLM     Status:  MEDLINE    
AIMS: To verify the efficiency of Calamintha officinalis essential oil as natural preservative in two current formulations. METHODS AND RESULTS: The 1.0 and 2.0% (v/v) C. officinalis essential oil was assayed for its preservative activity in two product types (cream and shampoo). The microbial challenge test was performed following the standards proposed by the European Pharmacopoeia Commission (E.P.) concerning topical preparations using standard micro-organisms and in addition wild strains, either in single or mixed cultures were used. The results clearly demonstrated that the C. officinalis essential oil at 2.0% concentration reduced the microbial inoculum satisfying the criterion A of the E.P. in the cream formulation and the criterion B in the shampoo formulation. Standard and wild strains showed a behaviour similar, both in cream and in shampoo formulation, with no significant difference (gerarchic variance, P > 0.05). CONCLUSION: C. officinalis essential oil confirmed its preservative properties but at higher concentration than that shown in previous studies on cetomacrogol cream. SIGNIFICANCE AND IMPACT OF THE STUDY: The nature of the formulation in which an essential oil is incorporated as preservative could have considerable effect on its efficacy.
A Nostro; M A Cannatelli; I Morelli; A D Musolino; F Scuderi; F Pizzimenti; V Alonzo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied microbiology     Volume:  97     ISSN:  1364-5072     ISO Abbreviation:  J. Appl. Microbiol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  395-401     Citation Subset:  IM    
Dipartimento Farmaco-Biologico, Sezione Microbiologia, Facoltá di Farmacia, Università di Messina, Messina, Italy.
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MeSH Terms
Anti-Infective Agents
Drug Contamination / prevention & control
Microbial Sensitivity Tests / methods
Oils, Volatile*
Plant Oils*
Plants, Medicinal
Preservatives, Pharmaceutical*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Cosmetics; 0/Oils, Volatile; 0/Ointments; 0/Plant Oils; 0/Preservatives, Pharmaceutical

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