Document Detail


Efficacy of verapamil in exercise-induced ventricular tachycardia.
MedLine Citation:
PMID:  4025168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antiarrhythmic efficacy of verapamil was determined by serial treadmill testing in 16 patients with reproducible exercise-induced ventricular tachycardia (VT). Twelve of the 16 patients responded to verapamil, 0.2 mg/kg intravenously; in 8 of these 12 responders, an oral verapamil regimen of 160 to 320 mg given every 8 hours also prevented exercise-induced VT. Plasma verapamil concentration was significantly higher in the responders than in the nonresponders to intravenous verapamil, but levels were similar in responders and nonresponders to oral therapy. The 8 responders to the oral drug were followed up while receiving verapamil therapy for 6 to 22 months (mean 15), and exercise-induced VT did not recur in any patient. Five of the 8 responders also had concomitant spontaneous VT unrelated to exercise which verapamil suppressed initially as well: 4 remained free of spontaneous VT, while 1 patient had recurrence of spontaneous VT. Thus, in patients with exercise-induced VT, verapamil is a promising alternative therapy to beta-adrenergic blocking agents. The effectiveness of verapamil is consistent with a mechanism of arrhythmogenesis involving calcium channels.
Authors:
A Woelfel; J R Foster; R G McAllister; R J Simpson; L S Gettes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  56     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-08-27     Completed Date:  1985-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  292-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Electrocardiography
Exercise Test*
Female
Follow-Up Studies
Heart Ventricles / physiopathology
Humans
Infusions, Parenteral
Male
Middle Aged
Tachycardia / drug therapy*,  etiology,  physiopathology
Verapamil / administration & dosage,  blood,  therapeutic use*
Grant Support
ID/Acronym/Agency:
HL 26484-02/HL/NHLBI NIH HHS; HL 27430/HL/NHLBI NIH HHS; RR-00046/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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