Document Detail


Efficacy of vasodilator therapy in canine model of acute pulmonary hypertension.
MedLine Citation:
PMID:  3142278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to determine 1) the effects of acute pulmonary embolization (induced by injection of autologous muscle) on right ventricular (RV) performance, coronary hemodynamics, and gas exchange; and 2) the efficacy of subsequent administration of nitroglycerin, prostaglandin E1, and hydralazine with regard to improvement in RV function and gas exchange in eight open-chest dogs. After embolization, pulmonary artery (PA) pressure and vascular resistance (PVR) increased three- to fivefold without changes in RV end-diastolic dimensions (ultrasonic dimension technique) or pressure. However, systolic dimensions increased, and stroke volume (SV) fell. Gas exchange, lung compliance, and pH worsened. Subsequent administration of nitroglycerin (5 micrograms.kg-1.min-1) and prostaglandin E1 (0.2 micrograms.kg-1.min-1) caused further decreases in SV and pH. In contrast, hydralazine (mean 0.15 mg/kg) improved myocardial segment shortening, SV, PVR, pulmonary artery flow, and gas exchange. Coronary blood flow increased by 110%. Thus in this canine model of combined pulmonary hypertension and respiratory insufficiency, nitroglycerin and prostaglandin E1 exerted no beneficial cardiopulmonary effects. In contrast, hydralazine improved regional and global RV performance and gas exchange.
Authors:
H J Priebe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  255     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-14     Completed Date:  1988-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1232-9     Citation Subset:  IM    
Affiliation:
Department of Anesthesia, University Hospital Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Alprostadil / therapeutic use
Animals
Coronary Circulation
Disease Models, Animal
Dogs
Female
Heart Ventricles / physiopathology
Hemodynamics
Hydralazine / therapeutic use
Hypertension, Pulmonary / drug therapy,  etiology,  physiopathology*
Lung / blood supply
Male
Nitroglycerin / therapeutic use
Pulmonary Embolism / complications,  physiopathology
Pulmonary Gas Exchange
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin; 745-65-3/Alprostadil; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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