| Efficacy of various treatment regimens, using liposomal streptomycin in cows with brucellosis. | |
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MedLine Citation:
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PMID: 2505648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty cows naturally infected with Brucella abortus were treated by various routes, using free or liposomal streptomycin or a combination of liposomal streptomycin and a long-acting oxytetracycline preparation. Of 21 cows treated with liposomal streptomycin alone, 3 (14%) were culture negative and 3 had 10 or fewer bacterial colonies isolated from tissues obtained at necropsy. Thirteen (62%) cows continued to shed organisms in udder secretions and were considered treatment failures. Of 9 cows that were given a combination of liposomal streptomycin and long-acting oxytetracycline, 5 (56%) were cured, 3 had 10 or fewer colonies on culture plates of tissue after necropsy and only 1 continued to shed B abortus in udder secretions after treatment. Eleven cows were given streptomycin liposomes by intramammary infusion with or without IM administration of long-acting oxytetracycline. The most effective regimen consisted of 2 intramammary infusions of streptomycin liposomes and 2 doses of oxytetracycline administered IM. Of 5 cows treated thusly, 2 were cured and all others had fewer than 10 B abortus colonies isolated from tissues obtained at necropsy. |
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Authors:
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P Nicoletti; R P Lenk; M C Popescu; C E Swenson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 50 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-10-05 Completed Date: 1989-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1004-7 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases, College of Veterinary Medicine, University of Florida, Gainesville 32610. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brucella abortus / drug effects Brucellosis, Bovine / drug therapy*, metabolism, microbiology Cattle Drug Carriers Drug Therapy, Combination / administration & dosage, therapeutic use Female Liposomes Mammary Glands, Animal / microbiology, secretion Oxytetracycline / administration & dosage, therapeutic use Streptomycin / administration & dosage*, blood, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Liposomes; 57-92-1/Streptomycin; 79-57-2/Oxytetracycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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