Document Detail

Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis.
MedLine Citation:
PMID:  4365115     Owner:  NLM     Status:  MEDLINE    
A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of Pneumocystis carinii pneumonitis in cortisonetreated rats. Although all of 15 untreated rats died with P. carinii pneumonitis, none of 15 given trimethoprim-sulfamethoxazole prophylactically acquired the infection. After P. carinii pneumonitis was established, 9 of 14 rats recovered after treatment with trimethoprim-sulfamethoxazole compared with only 2 of 14 treated with pentamidine isethionate. Rifampin and clindamycin, separately or in combination with pentamidine, were ineffective in the prevention and treatment of P. carinii infection.
W T Hughes; P C McNabb; T D Makres; S Feldman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  5     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1974 Mar 
Date Detail:
Created Date:  1974-08-16     Completed Date:  1974-08-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
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MeSH Terms
Alkanesulfonates / therapeutic use
Amidines / therapeutic use
Clindamycin / therapeutic use
Drug Therapy, Combination
Phenyl Ethers / therapeutic use
Pneumonia, Pneumocystis / drug therapy*,  prevention & control
Rifampin / therapeutic use
Sulfamethoxazole / administration & dosage*,  therapeutic use
Tetracycline / therapeutic use
Trimethoprim / administration & dosage*,  therapeutic use
Reg. No./Substance:
0/Alkanesulfonates; 0/Amidines; 0/Phenyl Ethers; 13292-46-1/Rifampin; 18323-44-9/Clindamycin; 60-54-8/Tetracycline; 723-46-6/Sulfamethoxazole; 738-70-5/Trimethoprim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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