Document Detail


Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis.
MedLine Citation:
PMID:  22788929     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE:   To evaluate the liver stiffness measurement (LSM) using transient elastography (TE) to predict the risk of esophageal varices (EVs) in Chinese patients.
METHODS:   In total, 46 patients with suspicious or proven liver cirrhosis underwent TE and liver biopsy. All participants were endoscopically screened for the presence of EVs and large EVs by two endoscopists who were blinded to the LSM status. Large EVs were defined as more than 5 mm in diameter. Receiver operating characteristic (ROC) curves for both TE and the platelet count/spleen diameter (PC/SD) ratio in predicting the presence of EVs or large EVs were calculated.
RESULTS:   Of the 46 patients, 30 (65%) had EVs including 19 (41%) with large EVs. The area under the ROC curve (AUROC) of LSM was 0.85 for the presence of EVs and 0.83 for large EVs, respectively. The cut-off values of LSM were ≥13.4 kPa for the presence of EVs and ≥14.6 kPa for large EVs. Notably, the AUROC of the PC/SD ratio was 0.92 for the presence of EVs but only 0.69 for large EVs.
CONCLUSION:   LSM using TE can predict the presence of EVs or large EVs in Chinese patients with suspicious or proven cirrhosis and may identify patients who require endoscopic surveillance.
Authors:
Huay-Min Wang; Gin-Ho Lo; Wen-Chi Chen; Ping-I Hsu; Hsien-Chung Yu; Chiun-Ku Lin; Hoi-Hung Chan; Wei-Lun Tsai; Feng-Woei Tsay; Tsan-Ping Liu; E-Ming Wang; Kwok-Hung Lai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  13     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  430-8     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital Department of Medical Education, Digestive Center, E-Da Hospital, I-Shou University Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung City National Yang-Ming University Department of General Medicine, Taipei Medical University, Taipei, Taiwan, China.
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