| Efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding: A systematic review. | |
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MedLine Citation:
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PMID: 22229782 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective. To evaluate the efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding. Design. Systematic review. Population: Women with diagnosis of idiopathic and non-functional heavy menstrual bleeding treated with tranexamic acid. Method. Electronic searches were conducted in literature database up to February 2011 by 2 independent reviewers. We included all trials involving efficacy of tranexamic acid for the treatment of heavy uterine bleeding. Pregnant, postmenopausal and cancer patients were excluded. Main outcome measures. Effect of tranexamic acid treatment on objective reduction of menstrual bleeding and improvement of patient quality of life. Results. A total of 10 studies met our inclusion criteria. Available evidence, indicates that tranexamic acid therapy in idiopathic menorrhagia women resulted in 34-54% reduction in menstrual blood loss compared to. Following tranexamic acid treatment patient's life quality parameters improved by 46-83% compared to 15-45% with norethisterone. When compared to placebo, tranexamic acid use significantly decreased the blood loss by 70% in women with menorrhagia secondary to intrauterine device (P<0.001). Limited evidence indicated potential benefit in fibroid patients with menorrhagia. No thromboembolic event was reported in all studies analyzed. Conclusion. Available evidence indicated that tranexamic acid treatment is effective and safe, and could potentially improve quality of life of patients presenting with idiopathic and non-functional heavy menstrual bleeding. Data on the therapeutic efficacy of tranexamic acid in patients with symptomatic fibroids is limited and further studies are therefore needed. |
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Authors:
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Becky Naoulou; Ming C Tsai |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: - ISSN: 1600-0412 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors AOGS© 2012 Nordic Federation of Societies of Obstetrics and Gynecology. |
Affiliation:
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Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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