Document Detail


Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats.
MedLine Citation:
PMID:  16228275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reports the efficacy of emodepside/praziquantel spot-on (Profender), Bayer AG, Leverkusen, Germany), a novel broad-spectrum anthelmintic for dermal application, against L4 larvae and immature adult and adult stages of Ancylostoma tubaeforme in cats. The formulation contains 2.14% (w/w) emodepside and 8.58% (w/v) praziquantel, with emodepside being active against gastrointestinal nematodes and praziquantel against cestodes. Five randomized, blinded and controlled laboratory studies demonstrated 100% efficacy of emodepside/praziquantel spot-on against mature A. tubaeforme and an efficacy of >95% and >97%, respectively, against L4 larvae and immature adults (based on worm counts after necropsy) at approximately the minimum proposed dose rate in cats of 3.0 mg emodepside and 12.0 mg praziquantel/kg body weight. No adverse reactions to the treatment were observed. It is concluded that emodepside/praziquantel spot-on is an effective and safe treatment against infections with mature and immature A. tubaeforme. Emodepside/praziquantel spot-on will considerably facilitate the treatment of cats against nematodes and cestodes compared with orally administered preparations.
Authors:
G Altreuther; F H M Borgsteede; J Buch; S D Charles; L Cruthers; C Epe; D R Young; K J Krieger
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Parasitology research     Volume:  97 Suppl 1     ISSN:  1432-1955     ISO Abbreviation:  Parasitol. Res.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  S51-7     Citation Subset:  IM    
Affiliation:
Bayer HealthCare AG, Animal Health Division, R&D Parasiticides, Leverkusen, Germany. gertraut.altreuther@bayerhealthcare.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Ancylostoma / drug effects
Ancylostomiasis / drug therapy,  veterinary*
Animals
Anthelmintics / administration & dosage,  therapeutic use
Cat Diseases / drug therapy*,  parasitology
Cats
Depsipeptides / administration & dosage*,  therapeutic use*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Praziquantel / administration & dosage*,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Depsipeptides; 0/emodepside; 55268-74-1/Praziquantel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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