| Efficacy of topical amoxicillin plus clavulanate/ticarcillin plus clavulanate and clindamycin in contaminated head and neck surgery: effect of antibiotic spectra and duration of therapy. | |
| | |
MedLine Citation:
|
PMID: 8077738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This prospective, randomized trial was designed to determine the efficacy and mechanism of action of topical mouthwash versus parenterally administered perioperative prophylactic antibiotics in contaminated head and neck surgery. Patients were randomly assigned to 1 of 4 treatment groups: 1 day of parenteral clindamycin (standard prophylaxis), 1 day of topical clindamycin, 5 days of topical clindamycin, or 1 day of topical amoxicillin plus clavulanate/ticarcillin plus clavulanate. Patients who received the latter regimen had fewer bacteria postoperatively compared with the other 3 treatment groups. The number of gram-negative aerobic bacilli on postoperative oral cavity cultures was increased in all 3 clindamycin groups but not in the amoxicillin plus clavulanate/ticarcillin plus clavulanate group. Parenteral clindamycin appears to exert its effect by being in the neck tissues at the time of surgery; however, all 3 topical regimens were more effective at reducing the number of bacteria in the neck viscera. Topical antibiotic prophylaxis was simple, safe, effective, and well tolerated. |
| | |
Authors:
|
J R Grandis; R M Vickers; J D Rihs; V L Yu; J T Johnson |
Related Documents
:
|
2644108 - Single-dose cefotetan vs. multiple-dose cefoxitin--antimicrobial prophylaxis in colorec... 19120528 - Discarding antimicrobial prophylaxis for transurethral resection of bladder tumor: a fe... 1290178 - Perioperative antibiotic prophylaxis in general thoracic surgery. 3726718 - A prospective randomized study of moxalactam versus gentamicin and clindamycin in penet... 20575978 - Prospective evaluation of combined oncological and functional outcomes after laparoscop... 13678388 - Evaluation of the effectiveness of laser in situ keratomileusis and photorefractive ker... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: 170 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1994 Sep |
Date Detail:
|
Created Date: 1994-10-06 Completed Date: 1994-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 729-32 Citation Subset: AIM; IM |
Affiliation:
|
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pennsylvania. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amoxicillin
/
administration & dosage,
therapeutic use* Anti-Bacterial Agents / therapeutic use Carcinoma, Squamous Cell / surgery* Clavulanic Acid Clavulanic Acids / administration & dosage, therapeutic use* Drug Administration Schedule Drug Therapy, Combination / therapeutic use* Gram-Negative Aerobic Bacteria / isolation & purification Head and Neck Neoplasms / surgery* Humans Laryngeal Neoplasms / surgery* Mouthwashes Prospective Studies Surgical Wound Infection / prevention & control* Ticarcillin / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Clavulanic Acids; 0/Mouthwashes; 26787-78-0/Amoxicillin; 34787-01-4/Ticarcillin; 58001-44-8/Clavulanic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in vaginal flora during pregnancy and association with preterm birth.
Next Document: Induction of hepatic pathology in SCID-Hu mice engrafted with peripheral blood lymphocytes of patien...