| Efficacy and tolerance of metamizole versus morphine for acute pancreatitis pain. | |
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MedLine Citation:
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PMID: 18235213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Morphine has been contraindicated for pain treatment in acute pancreatitis because of its presumed opioid-induced sphincter of Oddi dysfunction. However, scientific evidence supporting a deleterious influence on the clinical course is absent. This pilot study was undertaken to evaluate the efficacy and adverse events of metamizole versus morphine in acute pancreatitis. METHODS: 16 patients with acute pancreatitis were randomized to receive 10 mg/4 h s.c. (n = 8) morphine or 2 g/8 h i.v. (n = 8) metamizole. Pain scores were recorded every 4 h during 48 h after admission by a Visual Analogue Scale. Pethidine was additionally administered as a rescue therapy. RESULTS: 75% of patients achieved pain relief in the metamizole group versus 37.5% in the morphine group within 24 h of hospitalization (6/8 vs. 3/8; p: n.s.). The mean time to achieve pain relief was shorter in the metamizole group (10 +/- 6.6 vs. 17 +/- 18.3 h; p: n.s.). At the end of the study, 75% of patients achieved pain relief in the metamizole group versus 50% in the morphine group. Three patients in each group needed pethidine: 2 out of 3 achieved pain control in the metamizole group vs. 0 out of 3 in the morphine group. CONCLUSIONS: Intravenous metamizole shows a non-significant association with a quicker pain relief than morphine s.c. in acute pancreatitis. A larger randomized controlled trial should be desirable to confirm this result. and IAP. |
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Authors:
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A M Peiró; J Martínez; E Martínez; E de Madaria; P Llorens; J F Horga; M Pérez-Mateo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-01-31 |
Journal Detail:
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Title: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Volume: 8 ISSN: 1424-3911 ISO Abbreviation: Pancreatology Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-24 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966936 Medline TA: Pancreatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Clinical Pharmacology Unit, Hospital General Universitario de Alicante, Alicante, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analgesics, Opioid / therapeutic use* Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Dipyrone / therapeutic use* Female Humans Male Middle Aged Morphine / therapeutic use* Pain / drug therapy*, etiology Pancreatitis / complications* Pilot Projects |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 57-27-2/Morphine; 68-89-3/Dipyrone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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