Document Detail


Efficacy and tolerance of a 12-week treatment with inhaled formoterol in patients with reversible obstructive lung disease.
MedLine Citation:
PMID:  7824809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formoterol, a new beta 2-agonist, and salbutamol were given as aerosols twice and four times daily, respectively, to patients with reversible obstructive lung disease. The study was controlled and double blind, and continued for 12 weeks. Ninety-nine patients from five study centers were included and 89 patients could be properly evaluated. The formoterol-treated patients used significantly less rescue medicine (salbutamol aerosol) and had higher morning PEF values. For the other efficacy variables (daytime FEV1.0, evening PEF, patient and investigator global evaluations, night sleeping time) and tolerance (side effects noted by patients, blood and urine laboratory values, ECG, patient and investigator global evaluation), there were no significant differences between the formoterol- and the salbutamol-treated groups.
Authors:
G Stålenheim; T Wegener; L Grettve; B Lundbäck; B Melander; K Osterman; E Piitulainen; O Zetterström
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  61     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1994  
Date Detail:
Created Date:  1995-02-14     Completed Date:  1995-02-14     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  305-9     Citation Subset:  IM    
Affiliation:
Department of Lung Medicine, Akademiska sjukhuset, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adrenergic beta-Agonists / administration & dosage*,  adverse effects,  therapeutic use
Adult
Aged
Albuterol / administration & dosage,  adverse effects,  therapeutic use
Double-Blind Method
Ethanolamines / administration & dosage*,  adverse effects,  therapeutic use
Female
Forced Expiratory Volume
Humans
Lung Diseases, Obstructive / drug therapy*,  physiopathology
Male
Middle Aged
Peak Expiratory Flow Rate
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Ethanolamines; 18559-94-9/Albuterol; 5ZZ84GCW8B/formoterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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