Document Detail

Efficacy and tolerability of nonpenetrating filtering surgery with and without implant in treatment of open angle glaucoma: a quantitative evaluation of the evidence.
MedLine Citation:
PMID:  19295379     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy and tolerability of nonpenetrating filtering surgery augmented with implant (NPFSI) compared with nonpenetrating filtering surgery without implant (NPFS) in the treatment of patients with open angle glaucoma. METHODS: Pertinent studies were selected through extensive searches of the Cochrane Library, PubMed, Embase, and American Association of Ophthalmology (AAO) and Association for Research in Vision and Ophthalmology (ARVO) meeting abstracts. Seven controlled clinical trials meeting the predefined criteria were systematically reviewed by meta-analysis. The main outcome measures were percentage intraocular pressure (IOP) reduction, complete success rates, and qualified success rates. The pooled estimates were carried out in RevMan version 4.2 software. RESULTS: The weighted mean difference of the percentage IOP reduction from baseline were 6.7% (95% confidence intervals: -3.8 to 17.2) when comparing NPFSI with NPFS. NPFSI was associated with numerically greater, but nonsignificant, IOP lowering efficacy than NPFS. The pooled risk differences comparing NPFSI with NPFS were 0.13 (-0.02 to 0.28) in complete success rate and 0.09 (-0.04 to 0.21) in qualified success rate. Numerically greater, but nonsignificant, proportions of NPFSI patients than NPFS patients achieved the target end point IOP. NPFSI resulted in the same incidences of postoperative complications as NPFS. CONCLUSIONS: NPFSI was associated with equivalent efficacy to standard NPFS in lowering IOP. Comparable proportions of patients reached the IOP target with NPFSI and NPFS. Both surgeries were well tolerated.
Jin-Wei Cheng; Rui-Li Wei; Ji-Ping Cai; You Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of glaucoma     Volume:  18     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-19     Completed Date:  2009-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, China.
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MeSH Terms
Controlled Clinical Trials as Topic
Filtering Surgery / adverse effects,  methods*
Glaucoma, Open-Angle / physiopathology,  surgery*
Intraocular Pressure / physiology
Prostheses and Implants*
Treatment Outcome

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