| Efficacy and tolerability of natalizumab in relapsing-remitting multiple sclerosis patients: a post-marketing observational study. | |
| | |
MedLine Citation:
|
PMID: 20544247 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
To evaluate the efficacy and safety of natalizumab in patients with active relapsing-remitting multiple sclerosis (MS). We included 285 MS patients receiving natalizumab. Clinical, neuroradiological and safety data were registered every 6 months. Neutralizing antibodies (NABs) were tested after 6 months of treatment. After 1 year, the annualized relapse rate decreased to 0.26, with a significant reduction compared to the previous year (2.13). At 24 months the proportion of "relapse free" patients was 78% while that of "MRI free" patients was 69%. Considering clinical and MRI cumulative activity, "disease free" patients were 63% at 24 months. A total of 18 patients showed NABs positivity. We reported 34 cases of treatment interruptions. In conclusion, our data confirm the remarkable efficacy of natalizumab in a group of patients with higher disease activity than that of pivotal studies. |
| | |
Authors:
|
F Sangalli; L Moiola; S Bucello; P Annovazzi; A Rizzo; M Radaelli; G Vitello; L M E Grimaldi; A Ghezzi; V Martinelli; G Comi |
Related Documents
:
|
12325067 - Assessment of different treatment failure criteria in a cohort of relapsing-remitting m... 22632567 - Effect of intraperitoneal peridan™ concentrate adhesion reduction device on clinical ... 22566177 - Surgical success rate comparison in functional nasolacrimal duct obstruction: simple la... 7142417 - The treatment of nocturnal enuresis in institutionalized retarded adults. 8467837 - Effectiveness of botulinum toxin in the treatment of spasmodic torticollis. 23540627 - Indirect usage of miniscrew anchorage to intrude overerupted mandibular incisors in a c... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 31 Suppl 3 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-02-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
|
Languages: eng Pagination: 299-302 Citation Subset: IM |
Affiliation:
|
Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of zoledronic acid in the management of osteoporosis.
Next Document: Transient supranuclear paresis of the abduction in viral encephalitis of the brainstem.