Document Detail

Efficacy, tolerability, and kinetics of lamotrigine in infants.
MedLine Citation:
PMID:  12091848     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the efficacy, tolerability, and kinetics of lamotrigine during the first year of life.
STUDY DESIGN: We studied 13 infants with intractable seizures; 7 had partial seizures and 7 had infantile spasms (1 had both). Patients received open-label lamotrigine as add-on therapy for 3 months. Seizure frequency, response ratio, and side effects score were determined and compared with the baseline period.
RESULTS: The rate of partial seizures per day decreased from 8.57 +/- 2.29 to 4.00 +/- 2.15 (P =.027) and infantile spasms from 8.71 +/- 2.15 to 3.61 +/- 2.762 (P =.028). Apparent clearance increased during the first year of life, with a break point at 2 months of age (mean, 0.119 +/- 0.021, 0.217 +/- 0.094 L/h per kilogram for infants <2 months and those 2 to 12 months old, respectively,P <.001). Twenty-four-hour concentration to time plots of three 3- to 4-week-old neonates showed a half-life of 23.44 +/- 3.57 hours. Compared with a group of 17 older children, LTG had similar efficacy (response ratios, -0.68 +/- 0.12 and -0.74 +/- 0.11, P =.504), and similar adverse effects scores (0.67 +/- 0.67 and 0.23 +/- 0.166, P =.95).
CONCLUSIONS: Lamotrigine is a useful and well tolerated drug for partial seizures and infantile spasms in infants <1 year of age. However, lamotrigine has age-dependent kinetics that must be taken into consideration.
Mohamad A Mikati; Michel Fayad; Majed Koleilat; Nabil Mounla; Rania Hussein; Alia Kazma; Khalid Yunis
Related Documents :
2660288 - Are all neonatal seizures true epileptic seizures?
17701928 - Urinary tract infection in term neonates with prolonged jaundice.
7650548 - Symptomatic hypocalcemia and hypoparathyroidism in two infants of mothers with hyperpar...
23485498 - Scrotal abscess owing to candida albicans in a newborn.
23040328 - Labial ecthyma gangrenosum in an immunocompromised infant with leukemia: heightening aw...
2698158 - The endocrinology of feeding in the newborn.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  141     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-01     Completed Date:  2002-08-07     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  AIM; IM    
Department of Pediatrics, Adult and Pediatric Epilepsy Program, American University of Beirut, New York City, New York 10022, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Anticonvulsants / adverse effects,  pharmacokinetics*,  therapeutic use*
Epilepsies, Partial / drug therapy*
Infant, Newborn
Linear Models
Metabolic Clearance Rate
Spasms, Infantile / drug therapy*
Statistics, Nonparametric
Triazines / adverse effects,  pharmacokinetics*,  therapeutic use*
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia.
Next Document:  Effect of combination antiretroviral therapy on cerebrospinal fluid HIV RNA, HIV resistance, and cli...