| Efficacy of tocilizumab in refractory giant cell arteritis. | |
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MedLine Citation:
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PMID: 22284606 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Giant cell arteritis is the most frequent form of vasculitis characterized by a high risk of vascular thrombosis. Major complications are blindness and other vascular ischemia but bowel ischemic involvement is rare. Treatment is based on long-term steroid therapy with numerous side effects. The efficacy of immunosuppressive drugs like azathioprine methotrexate or anti-tumor necrosis factor antibodies appears to be too low to reduce the use of steroids. Th17 lymphocytes and interleukin-6 play an important role in pathogenesis of giant cell arteritis. We report here a case of effective interleukin-6 blocker in the treatment of refractory giant cell arteritis with ileitis and high-dose steroid dependence despite 2years of treatment with steroids and methotrexate. After infusions of tocilizumab, no relapse at 6months was found despite the decrease in corticosteroids. |
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Authors:
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Julien Vinit; Philip Bielefeld; Géraldine Muller; Jean-François Besancenot |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Joint, bone, spine : revue du rhumatisme Volume: - ISSN: 1778-7254 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100938016 Medline TA: Joint Bone Spine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved. |
Affiliation:
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Service de médecine interne et maladies systémiques, hôpital Général, University Hospital of Dijon, 3, rue Faubourg-Raines, 21033 Dijon cedex, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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