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Efficacy of tocilizumab in refractory giant cell arteritis.
MedLine Citation:
PMID:  22284606     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Giant cell arteritis is the most frequent form of vasculitis characterized by a high risk of vascular thrombosis. Major complications are blindness and other vascular ischemia but bowel ischemic involvement is rare. Treatment is based on long-term steroid therapy with numerous side effects. The efficacy of immunosuppressive drugs like azathioprine methotrexate or anti-tumor necrosis factor antibodies appears to be too low to reduce the use of steroids. Th17 lymphocytes and interleukin-6 play an important role in pathogenesis of giant cell arteritis. We report here a case of effective interleukin-6 blocker in the treatment of refractory giant cell arteritis with ileitis and high-dose steroid dependence despite 2years of treatment with steroids and methotrexate. After infusions of tocilizumab, no relapse at 6months was found despite the decrease in corticosteroids.
Authors:
Julien Vinit; Philip Bielefeld; Géraldine Muller; Jean-François Besancenot
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-25
Journal Detail:
Title:  Joint, bone, spine : revue du rhumatisme     Volume:  -     ISSN:  1778-7254     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100938016     Medline TA:  Joint Bone Spine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.
Affiliation:
Service de médecine interne et maladies systémiques, hôpital Général, University Hospital of Dijon, 3, rue Faubourg-Raines, 21033 Dijon cedex, France.
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