Document Detail


Efficacy of tiludronate in the treatment of horses with signs of pain associated with osteoarthritic lesions of the thoracolumbar vertebral column.
MedLine Citation:
PMID:  17331024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the efficacy of tiludronate for the treatment of horses with signs of pain associated with lesions of the thoracolumbar vertebral column. ANIMALS: 29 horses with clinical manifestations of pain associated with lesions of the thoracolumbar vertebral column and abnormal radiographic findings indicative of osteoarthritis of the articular processes-synovial intervertebral joints. PROCEDURES: Horses were initially examined in accordance with a standardized protocol, which included radiographic, ultrasonographic, and scintigraphic examinations. Fifteen horses were randomly assigned to receive tiludronate (1 mg/kg, IV, as a slow-rate infusion), and 14 horses received a control substance (day 0). Horses were monitored for the subsequent 120 days. Clinical evaluations were performed on days 60 and 120. Horses that had no evidence of clinical improvement on day 60 were administered tiludronate. Statistical analyses were performed to compare efficacy at day 60, improvement of dorsal flexibility at day 120, and dorsal flexibility before and 60 days after administration of tiludronate. RESULTS: Horses treated with tiludronate had significant improvement in dorsal flexibility between days 0 and 60, compared with control horses. Clinical improvement in dorsal flexibility was still evident at day 120. The percentage of positive responses was higher in the tiludronate group at 60 days. CONCLUSIONS AND CLINICAL RELEVANCE: Tiludronate had efficacy in the treatment of horses with signs of pain induced by osteoarticular lesions of the thoracolumbar vertebral column, causing a significant improvement in dorsal flexibility. Tiludronate may offer a treatment option for the management of horses with intervertebral lesions and the associated pain.
Authors:
Virginie Coudry; Dominique Thibaud; Barbara Riccio; Fabrice Audigié; David Didierlaurent; Jean-Marie Denoix
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of veterinary research     Volume:  68     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-37     Citation Subset:  IM    
Affiliation:
Centre d'Imagerie et de Recherche sur les Affections Locomotrices Equines, Ecole Nationale Vétérinaire d'Alfort, Unité Mixte de Recherche, Institut National de Recherche Agronomique 957, RN 175, 14430 Goustranville, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Density Conservation Agents / therapeutic use
Diphosphonates / therapeutic use*
Horse Diseases / drug therapy*
Horses
Lumbar Vertebrae / pathology*
Osteoarthritis / complications,  drug therapy,  veterinary*
Pain / drug therapy,  etiology,  veterinary*
Thoracic Vertebrae / pathology*
Chemical
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 89987-06-4/tiludronic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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