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Efficacy of terbutaline in familial limb girdle myasthenia: Case report and review of literature.
MedLine Citation:
PMID:  23956565     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Congenital myasthenic syndromes (CMS) are frequently misdiagnosed due to their wide clinical heterogeneity. Molecular defects in various end-plate associated proteins are being identified. Better understanding of the molecular pathogenesis and genotype-phenotype correlations can help evolve newer therapeutic targets. We present a report of two siblings with familial limb girdle myasthenia who showed significant objective clinical improvement after initiation of terbutaline. The possible mechanism of action and utility of terbutaline in the setting of CMS are described. Terbutaline is a potential treatment option in certain subtypes of CMS refractory to conventional medicines. However, long-term follow-up is required to determine the overall efficacy and safety profile.
Authors:
Zeyaur Rahman Azad; Ajith Sivadasan; Mathew Alexander; Anil Kumar B Patil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of Indian Academy of Neurology     Volume:  16     ISSN:  0972-2327     ISO Abbreviation:  Ann Indian Acad Neurol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-08-19     Completed Date:  2013-08-19     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  101273955     Medline TA:  Ann Indian Acad Neurol     Country:  India    
Other Details:
Languages:  eng     Pagination:  208-10     Citation Subset:  -    
Affiliation:
Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
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