Document Detail


Efficacy of tamsulosin in medical expulsive therapy for distal ureteral calculi.
MedLine Citation:
PMID:  17853008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the potential role of tamsulosin in the medical treatment of distal ureteral stones. MATERIAL AND METHODS: Ninety patients with symptomatic distal ureteral calculi were enrolled. They were randomly divided into two groups: Group A (n=45) received diclofenac 100 mg on demand for 4 weeks plus levofloxacin 250 mg daily for the first week and were well hydrated; and Group B (n=45) received the same therapy plus tamsulosin 0.4 mg/daily for 4 weeks. Abdominal ultrasound scans and KUB X-rays were performed weekly. Stone expulsion rates, time to expulsion, pain episodes and analgesic usage were determined. Intervention by means of shock-wave lithotripsy (SWL) or ureteroscopy was evaluated. RESULTS: The stone expulsion rate was 51.1% for Group A, compared to 88.9% for Group B (p=0.001). The average time to expulsion was 12.53+/-2.12 days for Group A and 7.32+/-0.78 days for Group B (p=0.04). The number of pain episodes was significantly lower in Group B and mean use of analgesics was lower for Group B (0.14+/-0.5 vials) than Group A (2.78+/-2.7 vials). Twenty-two patients in Group A failed to pass their stones after 4 weeks but only five in Group B. Of the patients who were not stone-free, 19 were treated with SWL and eight underwent ureteroscopy. CONCLUSION: Our study reveals the efficacy of tamsulosin for the treatment of distal ureteral stones. Tamsulosin should be added to the standard medical approach for treating these stones.
Authors:
Mohamed Abdel-Basir Sayed; Ahmad Abolyosr; Medhat Ahmad Abdalla; Ahmad Shehata El-Azab
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-08-24
Journal Detail:
Title:  Scandinavian journal of urology and nephrology     Volume:  42     ISSN:  0036-5599     ISO Abbreviation:  Scand. J. Urol. Nephrol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-19     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0114501     Medline TA:  Scand J Urol Nephrol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Affiliation:
Urology Department, Assiut University, Assiut, Egypt. sayedmohamed_22@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic alpha-Antagonists / therapeutic use*
Adult
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Diclofenac / therapeutic use
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Male
Middle Aged
Sulfonamides / therapeutic use*
Time Factors
Treatment Outcome
Ureteral Calculi / diagnosis,  drug therapy*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Sulfonamides; 106133-20-4/tamsulosin; 15307-86-5/Diclofenac

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