| Efficacy of synthetic glue treatment of high crypoglandular fistula-in-ano. | |
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MedLine Citation:
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PMID: 20674201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: In France, seton drainage followed by fistulotomy is currently the standard treatment for high cryptoglandular fistula-in-ano. Biological or synthetic glues, such as Glubran(®) 2, have been recently proposed for sealing the fistula tract. The purpose of this study is to determine the healing rate with glubran 2 and to assess the functional outcome after cure of fistula-in-ano. PATIENTS AND METHODS: From July 2006 to July 2008, 34 patients (20 males; median age 48.5 years, range 22-55 years) with high cryptoglandular anal fistulas were treated with glubran 2. Patients were seen for physical examination at 1, 3 and 6 months, then interviewed by telephone at 1 and 2 years, and in September 2009. The Fecal incontinence severity index (FISI) score was used to assess continence. RESULTS: The healing rate at 1 month was 67.6% (23 patients); the fistula failed to heal in 11 patients. All 23 patients with a healed fistula remained recurrence-free, with no continence disorders noted, during the median 34-month follow-up period (range 21-43 months). One patient was lost to follow-up after 6 months. CONCLUSION: Glubran 2 provides an effective treatment for high fistula-in-ano, with no change in continence. In future, a randomized comparison of this agent with fibrin glues should be useful. |
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Authors:
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M Queralto; G Portier; G Bonnaud; J-P Chotard; P Cabarrot; F Lazorthes |
Publication Detail:
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Type: Journal Article Date: 2010-07-31 |
Journal Detail:
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Title: Gastroentérologie clinique et biologique Volume: 34 ISSN: 2210-7401 ISO Abbreviation: Gastroenterol. Clin. Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704825 Medline TA: Gastroenterol Clin Biol Country: France |
Other Details:
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Languages: eng Pagination: 477-82 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Service de colo proctologie, clinique des Cèdres, Cornebarrieu, France. michel.queralto@wanadoo.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cutaneous Fistula / surgery* Cyanoacrylates / adverse effects, therapeutic use* Fecal Incontinence / prevention & control Female Humans Male Middle Aged Pain / etiology Patient Preference Postoperative Complications / etiology Rectal Fistula / surgery* Tissue Adhesives / adverse effects, therapeutic use* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cyanoacrylates; 0/Tissue Adhesives; 0/glubran 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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