Document Detail

Efficacy of synthetic glue treatment of high crypoglandular fistula-in-ano.
MedLine Citation:
PMID:  20674201     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In France, seton drainage followed by fistulotomy is currently the standard treatment for high cryptoglandular fistula-in-ano. Biological or synthetic glues, such as Glubran(®) 2, have been recently proposed for sealing the fistula tract. The purpose of this study is to determine the healing rate with glubran 2 and to assess the functional outcome after cure of fistula-in-ano.
PATIENTS AND METHODS: From July 2006 to July 2008, 34 patients (20 males; median age 48.5 years, range 22-55 years) with high cryptoglandular anal fistulas were treated with glubran 2. Patients were seen for physical examination at 1, 3 and 6 months, then interviewed by telephone at 1 and 2 years, and in September 2009. The Fecal incontinence severity index (FISI) score was used to assess continence.
RESULTS: The healing rate at 1 month was 67.6% (23 patients); the fistula failed to heal in 11 patients. All 23 patients with a healed fistula remained recurrence-free, with no continence disorders noted, during the median 34-month follow-up period (range 21-43 months). One patient was lost to follow-up after 6 months.
CONCLUSION: Glubran 2 provides an effective treatment for high fistula-in-ano, with no change in continence. In future, a randomized comparison of this agent with fibrin glues should be useful.
M Queralto; G Portier; G Bonnaud; J-P Chotard; P Cabarrot; F Lazorthes
Publication Detail:
Type:  Journal Article     Date:  2010-07-31
Journal Detail:
Title:  Gastroentérologie clinique et biologique     Volume:  34     ISSN:  2210-7401     ISO Abbreviation:  Gastroenterol. Clin. Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704825     Medline TA:  Gastroenterol Clin Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  477-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Service de colo proctologie, clinique des Cèdres, Cornebarrieu, France.
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MeSH Terms
Aged, 80 and over
Cutaneous Fistula / surgery*
Cyanoacrylates / adverse effects,  therapeutic use*
Fecal Incontinence / prevention & control
Middle Aged
Pain / etiology
Patient Preference
Postoperative Complications / etiology
Rectal Fistula / surgery*
Tissue Adhesives / adverse effects,  therapeutic use*
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Cyanoacrylates; 0/Tissue Adhesives; 0/glubran 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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