Document Detail


Efficacy of a substituted methyl benzimidazole carbamate against developing and adult helminth parasites.
MedLine Citation:
PMID:  3564348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of a substituted methyl benzimidazole carbamate, methyl 5(6)-[4-N-(2-pyridyl)] piperazino carbamoyl benzimidazole-2-carbamate, was assessed against larval and adult forms of Ancylostoma ceylanicum (hookworm), Nippostrongylus brasiliensis (trichostrongylid), Hymenolepis nana (tapeworm) and Brugia malayi (filariid) in experimentally-infected animals. The compound was found to have high efficacy against the developing stages (L3, L4, L5) of A. ceylanicum in hamsters at a single dose of 12.5 mg kg-1, against larvae of N. brasiliensis at 17.5 mg kg-1 and against cysticercoids of Hymenolepis nana at 100 mg kg-1 daily for 3 days given per os (p.o.) or intraperitoneally (i.p.). All the stages of B. malayi in Mastomys were killed when the compound was given i.p. at a dose of 6.25 mg kg-1 for 5 consecutive days. A dose of 6.25 mg kg-1 eliminated all adult A. ceylanicum from infected hamsters, 100 mg kg-1 resulted in complete removal of Syphacia obvelata adults from 63.6% of infected mice, 25 mg kg-1 X 5 dose eliminated 100% of adult B. malayi from infected Mastomys and a single 50 mg kg-1 dose expelled all H. nana adults from infected rats.
Authors:
J C Katiyar; A Misra; S Gupta; P K Visen; P K Murthy; A B Sen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary parasitology     Volume:  23     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-15     Completed Date:  1987-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-204     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ancylostoma / drug effects*
Ancylostomiasis / drug therapy,  veterinary
Animals
Benzimidazoles / pharmacology*,  therapeutic use
Brugia / drug effects*
Carbamates / pharmacology*,  therapeutic use
Cricetinae
Female
Filariasis / drug therapy,  veterinary
Hymenolepiasis / drug therapy,  veterinary
Hymenolepis / drug effects*
Larva / drug effects
Male
Mice
Muridae
Nematode Infections / drug therapy,  veterinary
Nippostrongylus / drug effects*
Rats
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Carbamates; 93522-20-4/CDRI 81-470

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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