| Efficacy of a substituted methyl benzimidazole carbamate against developing and adult helminth parasites. | |
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MedLine Citation:
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PMID: 3564348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of a substituted methyl benzimidazole carbamate, methyl 5(6)-[4-N-(2-pyridyl)] piperazino carbamoyl benzimidazole-2-carbamate, was assessed against larval and adult forms of Ancylostoma ceylanicum (hookworm), Nippostrongylus brasiliensis (trichostrongylid), Hymenolepis nana (tapeworm) and Brugia malayi (filariid) in experimentally-infected animals. The compound was found to have high efficacy against the developing stages (L3, L4, L5) of A. ceylanicum in hamsters at a single dose of 12.5 mg kg-1, against larvae of N. brasiliensis at 17.5 mg kg-1 and against cysticercoids of Hymenolepis nana at 100 mg kg-1 daily for 3 days given per os (p.o.) or intraperitoneally (i.p.). All the stages of B. malayi in Mastomys were killed when the compound was given i.p. at a dose of 6.25 mg kg-1 for 5 consecutive days. A dose of 6.25 mg kg-1 eliminated all adult A. ceylanicum from infected hamsters, 100 mg kg-1 resulted in complete removal of Syphacia obvelata adults from 63.6% of infected mice, 25 mg kg-1 X 5 dose eliminated 100% of adult B. malayi from infected Mastomys and a single 50 mg kg-1 dose expelled all H. nana adults from infected rats. |
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Authors:
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J C Katiyar; A Misra; S Gupta; P K Visen; P K Murthy; A B Sen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Veterinary parasitology Volume: 23 ISSN: 0304-4017 ISO Abbreviation: Vet. Parasitol. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-05-15 Completed Date: 1987-05-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7602745 Medline TA: Vet Parasitol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 193-204 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ancylostoma
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drug effects* Ancylostomiasis / drug therapy, veterinary Animals Benzimidazoles / pharmacology*, therapeutic use Brugia / drug effects* Carbamates / pharmacology*, therapeutic use Cricetinae Female Filariasis / drug therapy, veterinary Hymenolepiasis / drug therapy, veterinary Hymenolepis / drug effects* Larva / drug effects Male Mice Muridae Nematode Infections / drug therapy, veterinary Nippostrongylus / drug effects* Rats |
| Chemical | |
Reg. No./Substance:
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0/Benzimidazoles; 0/Carbamates; 93522-20-4/CDRI 81-470 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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