Document Detail

Efficacy of a substituted methyl benzimidazole carbamate against developing and adult helminth parasites.
MedLine Citation:
PMID:  3564348     Owner:  NLM     Status:  MEDLINE    
The efficacy of a substituted methyl benzimidazole carbamate, methyl 5(6)-[4-N-(2-pyridyl)] piperazino carbamoyl benzimidazole-2-carbamate, was assessed against larval and adult forms of Ancylostoma ceylanicum (hookworm), Nippostrongylus brasiliensis (trichostrongylid), Hymenolepis nana (tapeworm) and Brugia malayi (filariid) in experimentally-infected animals. The compound was found to have high efficacy against the developing stages (L3, L4, L5) of A. ceylanicum in hamsters at a single dose of 12.5 mg kg-1, against larvae of N. brasiliensis at 17.5 mg kg-1 and against cysticercoids of Hymenolepis nana at 100 mg kg-1 daily for 3 days given per os (p.o.) or intraperitoneally (i.p.). All the stages of B. malayi in Mastomys were killed when the compound was given i.p. at a dose of 6.25 mg kg-1 for 5 consecutive days. A dose of 6.25 mg kg-1 eliminated all adult A. ceylanicum from infected hamsters, 100 mg kg-1 resulted in complete removal of Syphacia obvelata adults from 63.6% of infected mice, 25 mg kg-1 X 5 dose eliminated 100% of adult B. malayi from infected Mastomys and a single 50 mg kg-1 dose expelled all H. nana adults from infected rats.
J C Katiyar; A Misra; S Gupta; P K Visen; P K Murthy; A B Sen
Related Documents :
2603208 - Comparison of antimalarial efficacy of artemisinin (qinghaosu) and arteether against pl...
7122068 - Studies on haemonchus contortus. vii. the effect of treatment of trichostrongylus axei ...
2974008 - Chemotherapy of experimental toxoplasmosis with special reference to robenidine.
8257368 - Effect of spectinomycin on escherichia coli infection in 1-day-old ducklings.
8415868 - Antihypertensive activity of abbott-81282, a nonpeptide angiotensin ii antagonist, in t...
8471408 - The reproducibility of quinine bioavailability.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary parasitology     Volume:  23     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-15     Completed Date:  1987-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-204     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ancylostoma / drug effects*
Ancylostomiasis / drug therapy,  veterinary
Benzimidazoles / pharmacology*,  therapeutic use
Brugia / drug effects*
Carbamates / pharmacology*,  therapeutic use
Filariasis / drug therapy,  veterinary
Hymenolepiasis / drug therapy,  veterinary
Hymenolepis / drug effects*
Larva / drug effects
Nematode Infections / drug therapy,  veterinary
Nippostrongylus / drug effects*
Reg. No./Substance:
0/Benzimidazoles; 0/Carbamates; 93522-20-4/CDRI 81-470

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Egg polymorphism of Schistosoma bovis.
Next Document:  Comparison of ivermectin and thiabendazole for treatment of naturally occurring nematode infections ...