Document Detail

Efficacy of steroid therapy for pacing failure in a patient with chronic myocarditis.
MedLine Citation:
PMID:  15098603     Owner:  NLM     Status:  MEDLINE    
A 66-year-old man had a progressive increase in the pacing threshold over a one-year period, resulting from chronic myocarditis. Following steroid therapy, the pacing threshold decreased and became stabilized, and was accompanied by a decrease in the serum creatine kinase, cardiac myosin light chains and pro-collagen III peptide values, but cardiac function did not improve. Endocardial biopsy showed that there was no progression in the fibrosis. The pacing failure improved, but the cardiac function did not. It was believed that the steroid therapy suppressed the progression of the inflammation and fibrosis caused by the chronic myocarditis.
Nobuyuki Mitsuya; Ryoji Kishi; Noriyuki Suzuki; Masachika Tamura; Yukiko Imai; Osamu Tanaka; Akihiko Takagi; Kiyoshi Nakazawa; Fumihiko Miyake; Sachihiko Nobuoka; Jyunki Koike
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  43     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-21     Completed Date:  2004-07-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki.
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MeSH Terms
Cardiac Pacing, Artificial*
Chronic Disease
Creatine Kinase / blood
Disease Progression
Glucocorticoids / administration & dosage,  therapeutic use
Heart Ventricles / pathology
Methylprednisolone / administration & dosage
Myocarditis / blood,  complications*,  drug therapy*,  physiopathology
Myocardium / pathology
Peptide Fragments / blood
Prednisolone / administration & dosage,  therapeutic use
Procollagen / blood
Sick Sinus Syndrome / drug therapy,  etiology*
Treatment Failure
Ventricular Function, Left
Reg. No./Substance:
0/Glucocorticoids; 0/Peptide Fragments; 0/Procollagen; 0/procollagen Type III-N-terminal peptide; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone; EC Kinase
Comment In:
Intern Med. 2004 Mar;43(3):167-8   [PMID:  15098590 ]

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